摘要
目的:了解RSV和HRV在ALRTI住院儿童中流行病学和临床特征的异同。方法:收集2007年9月~2008年8月ALRTI住院患儿NPA样本,进行病毒核酸检测,统计分析RSV和HRV检出病例的流行状况、临床特点。结果:1165名患儿检出RSV 315例(27.0%),HRV 202例(17.3%);性别之间检出率无统计学差异;RSV检出患儿平均年龄13.1±14.3月,1岁以下检出率最高,且明显高于同年龄段HRV检出率;HRV检出患儿平均年龄15.8±17.8月,1岁检出率最高,并高于同年龄段RSV检出率;RSV检出以11月份到次年2月份为高峰;HRV检出以4月份、9~12月份为高峰;与RSV比较,HRV检出病例临床特点除末梢血白细胞计数升高较多见外,其它均无差异;与单一RSV检出病例比较,RSV混合其它病毒检出病例并发症较多,且末梢血白细胞计数升高较多见;单一HRV检出病例未见发绀,其余临床特点与混合其它病毒检出病例无差异。结论:RSV和HRV是长沙地区ALRTI住院儿童的重要病原体,两者在年龄、季节分布上有不同,临床特点无明显差别。
Objective To compare with the difference of epidemiology and clinical features between respiratory syncytial virus(RSV) and human rhinovirus(HRV) infection in hospit-alized children with acute lower respiratory tract infection(ALRTI) in Changsha.Methods 1165 nasopharyngeal aspirates(NPA)specimens were collected in hospitalized children with ALRTI from 2007.9 to 2008.8 in Changsha.Clinical characteristics and epidemiology fea-tures of RSV infections were compared with HRV infections in children.Results RSV was detected in 315 patients(27.04%) of the 1165 children.,HRV was detected in 202 patie-nts(17.3%).There is no significant difference in detection rate between male and female(X2=0.079,P=0.778).The average age of RSV infected children was 13.1±14.3 month and The detected rate was the highest in children with less than 1 year old,The detected rateof RSV infections is significantly higher than HRV infected children with less than 1 year old(X2=47.464,P=0.000).The average age of HRV infected children was 15.8±17.8 month and the positive detection rate was the highest in children with 1 year old,The detected rate of HRV infections is significantly higher than RSV infected children with 1 year old(X2=13.377,P=0.000).The peak seasons of RSV infection were November to February in the second year.the prevalence of HRV infection appeared in April and Septe-mber to December.Compared with RSV infected children,a higher white blood cell coun-ting(X2=6.442,P=0.011)were detected in HRV infected children,rest clinical characteristics were no significant difference(P>0.05).Compared with RSV single infected children,a hi-gher complication rate(X2=4.298,P=0.041)and white blood cell counting(X2=4.666,P=0.031)were detected in RSV mixed infected children.With the exception of cyanosis,no sig-ni?cant clinical differences were found between HRV single and mixed infections(P>0.05).Conclusion RSV and HRV were important pathogens in children with ALRTI in Changsha.Age and season distribution were clearly different,but clinical charact
出处
《湖南师范大学学报（医学版）》
2012年第2期28-32,共5页
Journal of Hunan Normal University(Medical Sciences)
关键词
急性下呼吸道感染
呼吸道合胞病毒
鼻病毒
儿童
acute lower respiratory tract infection
respiratory syncytial virus
human rhinovirus
children
