摘要
硼酸盐玻璃具有优异的生物相容性、降解性和骨传导性,在骨组织修复领域受到一定的关注。目前,硼酸盐玻璃的主要应用形式是支架和微球,而有关硼酸盐玻璃基骨水泥的制备及性能研究却较少涉及。基于孔隙在骨组织修复材料工程领域中的重要作用,本研究以NaHCO_3和柠檬酸为气体发泡剂制备可注射的多孔硼酸盐玻璃基骨水泥,通过SEM、XRD和FTIR等方法表征其对骨水泥性能的影响。结果表明:发泡骨水泥具有良好的注射性,其注射率高达80%。SEM形貌照片显示骨水泥中大孔已被成功引入,且孔隙连通,其孔径介于10μm到800μm之间。浸泡结果表明,发泡骨水泥失重率明显提高。PBS溶液中浸泡30 d后,发泡骨水泥的失重率高达70%,而非发泡的骨水泥的失重率只有50%。此外,XRD和FTIR的结果表明,浸泡产物为羟基磷灰石(HA)。ATR的结果进一步证明了BBG和PBS溶液的反应机理,表明BBGC中孔隙的引入大大加快了其降解,促进了矿化反应的进行。
Borate bioactive glass（BBG） is a promising candidate material for bone tissue engineering. Mostly, it was applied in the form of scaffolds and granules. Till now, little work has been done to investigate the fabrication of porous borate bioactive glass cement（BBGC）. In this work, we prepared an injectable macroporous BBGC via gas-foaming method, where NaHCO3 and citric acid were used as porogen. Porous structure was analyzed by using SEM. The properties of soaking products were characterized by XRD, FTIR and ATR. The injection test showed that the injection rate of BBGC was over 80%. SEM images presented that there were apparent pores in BBGC. The diameter of the macropores varied from 10 μm to 800 μm. Furthermore, the degradability of BBGC was greatly improved. After one month in vitro soaking, the weight loss of non-foamed BBGC was only 50wt%, while for the foamed samples, their weight loss reached 70wt%. Meanwhile, the XRD, FTIR and ATR results exhibited that there were hydroxyapatite（HA） formation and confirmed that the introduction of macropores into the BBGC did facilitate the mineralization reaction.
作者
吴莹莹
叶松
姚爱华
李海滨
贾伟涛
黄文旵
王德平
WU Ying-Ying YE Song YAO Ai-Hua LI Hai-Bin JIA Wei-Tao HUANG Wen-Hai WANG De-Ping(School of Materials Science and Engineering, Tongji University, Shanghai 201804, China Department of Orthopaedic Surgery Shanghai Sixth People＇s Hospital, Jiaotong University, Shanghai 200233, China)
出处
《无机材料学报》
SCIE
EI
CAS
CSCD
北大核心
2017年第7期777-784,共8页
Journal of Inorganic Materials
基金
National Natural Science Foundation of China(51372170,81572105)
关键词
硼酸盐玻璃基骨水泥
气体发泡
大孔
快速降解
gas-foaming
bioactive borate glass cement（BBGC）
macropores
fast-degrading
