摘要
目的 探讨亲属活体供肾肾小球滤过率与受者体重比值（Dg/Rw）对移植肾术后早期肾功能的的预测作用.方法 回顾性分析2014年1月至2015年7月间108例亲属活体肾移植的供、受者资料,排除：非首次移植或联合移植者;术后发生肾功能恢复延迟（DGF）者;术后1年随访期内发生超急性、加速性、急性排斥反应者;术后检查提示肾动脉狭窄和移植肾肾积水者,最终纳入90例.根据Dg/Rw将90例受者分为G1组（Dg/Rw≤0.81,25例）、G2组（0.82＜Dg/Rw＜ 1.11,36例）、G3组（Dg/Rw≥1.12,29例）.观察三组受者术后3d、7d、1个月、1年的血肌酐水平与Dg/Rw的关系.结果 受者术后3d、7d、1个月及1年血肌酐均与Dg/Rw呈线性关系（P＜0.05）.术后1年内,G1、G2组血肌酐均高于G3组（P＜0.05）,且G1、G2组早期血肌酐下降趋势也较G3组慢（P＜0.05）;但G1、G2组之间不同时间点血肌酐值的差异无统计学意义.结论 Dg/Rw较高的受者术后早期肌酐水平下降较快,且维持在较低水平.Dg/Rw对肾移植后早期受者肾功能有一定的预测作用.
Objective To investigate whether the donor＇s glomerular filtration rate （GFR） to recipient＇s weight ratio （Dg/Rw） is a useful tool to predict early clinical outcome in living-related do-nor transplantation.Methods A total number of 108 living donor transplant recipients in the Chinese Military 309th Hospital from Jan.2014 to July 2015 were enrolled in this study.The patients who had multi-organ transplantation or developed grafts rejection,delayed graft function,hydronephrosis or renal vascular stenosis were excluded.The 90 qualified recipients were divided into G1 group （Dg/Rw ≤0.81）,G2 group （Dg/Rw 0.81～1.11）,and G3 group （Dg/Rw≥1.12）.We respectively analyzed the relationship between recipient＇s serum creatinine Scr and Dg/Rw at 3-,7-,30-day and 1 year after transplantation.Results Scr at 3-,7-,30-day and 1 year after transplantation had linear correlation with Dg/Rw.As compared with G1 and G2 groups,Scr level was significantly reduced in G3 group at different time points （P〈0.05）.Conclusion Dg/Rw has a negative relationship with Scr level after renal transplantation.Pre-transplant Dg/Rw is a potential index to predict the early clinical outcome in living-related donor transplantation.
出处
《中华器官移植杂志》
CAS
CSCD
2017年第3期160-164,共5页
Chinese Journal of Organ Transplantation
基金
国家自然科学基金项目（81470043）
关键词
肾移植
肾小球滤过率
肾功能
Kidney transplantation
Glomerular filtration rate
Renal function
