摘要
目的通过临床调查药物性肝损害(DILI)的证素特点,分析DILI患者中医证素的分布特点,以及DILI各分型的中医证素分布特点。方法将103例DILI患者分为肝细胞损伤型、胆汁瘀积型和混合型,建立数据库,运用SPSS21.0对数据进行频次、频率的描述分析。结果 103例DILI患者病位证素前五位顺序为脾、肝、胆、胃、肾;病性证素前四位顺序为湿、火热、气虚、气滞。以DILI不同分型进行统计学分析,肝细胞损伤型患者主要病位证素顺序为脾、肝、胆,病性主要证素顺序为湿、火热、气虚;胆汁瘀积型患者病位证素顺序为脾、肝,病性主要证素顺序为湿、气虚、火热、气滞;混合型患者病位证素顺序为肝、脾、胃,病性主要证素的顺序为湿、火热、气滞。结论 DILI的核心病位多与脾、肝、胆,与胃、肾相关。其病理演变多以湿、火热、气虚、气滞为主。其三种分型中,肝细胞损伤型病位多在脾、肝、胆,其病理演变多以湿、火热、气虚为主;胆汁瘀积型病位多在脾、肝,其病理演变多以湿、气虚、火热、气滞为主;混合型病位多在肝、脾、胃,其病理演变多以湿、火热、气滞为主。
Objective To analyze the distribution characteristics of TCM differentiation elements of drug-induced liver lesion（ DILI） and the distributions of each type of DILI through the clinical investigation of pattern/syndrome differentiation characteristics of DILI. Methods One hundred and three cases of DILI were divided into hepatocyte damage type,cholestasis type and mixed type. The database was set up. SPSS21. 0 was used to have the descriptive analysis on the frequency of data. Results In 103 cases of DILI,regarding the location of sickness,the top five syndrome factors were spleen,liver,gallbladder,stomach and kidney; regarding the property of disease,the top four factors were damp,fire and heat,qi deficiency and qi stagnation. In the statistical analysis on the different DILI types,for the hepatocyte damage type,regarding the location of sickness,the sequence of factors was spleen,liver and gallbladder; regarding the property of disease,the sequence was damp,fire and heat,and qi deficiency. For the cholestasis type,the sequence was spleen and liver for the location of sickness and was damp,qi deficiency,fire and heat and qi stagnation for the property of disease. For the mixed type,the sequence was liver,spleen and stomach for the location of sickness and was damp,fire and heat and qi stagnation for the property of disease. Conclusion The essential location of sickness of DILI is mostly related to spleen,liver,gallbladder,stomach and kidney. For the pathologic evolution,damp,fire and heat,qi deficiency and qi stagnation are mainly involved. For the hepatocyte damage type,the location of sickness is in spleen,liver and gallbladder,and damp,fire and heat and qi deficiency are involved in the pathological evaluation. For the cholestasis type,the location of sickness is in spleen and liver,and damp,qi deficiency,fire and heat and qi stagnation are involved in the pathological evaluation. For the mixed type,the location of sickness is in liver,spleen and stomach and damp,fire and heat and qi stagnation are involv
作者
张倩
王健
郭卉
ZHANG Qian WANG Jian GUO Hui(Tianjin University of Traditional Chinese Medicine ,Tianjin 300193)
出处
《世界中西医结合杂志》
2017年第6期837-840,共4页
World Journal of Integrated Traditional and Western Medicine
关键词
药物性肝损伤
分型
中医证素
Drug-Induced Liver Lesion
Type Division
TCM Differentiation Elements
