摘要
目的观察养血醒脑方治疗脑卒中后精神障碍的疗效及对病人认知功能、行为能力的影响。方法 166例脑卒中后精神障碍病人随机分为观察组(85例)与对照组(81例)。对照组给予喹硫平治疗,观察组在对照组的基础上给予养血醒脑方治疗。治疗4周并随访4周,观察两组疗效及简易精神状态量表(MMSE)、日常生活活动能力量表(ADL)评分变化。结果观察组痊愈率67.06%,显著进步率17.64%,好转率11.76%,无效率2.35%;对照组痊愈率51.85%,显著进步率28.40%,好转率19.75%,无效率7.41%。两组疗效比较差异有统计学意义(P<0.05)。两组MMSE评分比较差异有统计学意义(F_(分组)=5.634,P<0.05),两组MMSE评分随着时间的延长表现出逐渐升高的趋势(F_(时间)=10.146,P<0.05),观察组升高的幅度大于对照组(F_(交互)=3.105,P<0.05);两组ADL评分比较差异有统计学意义(F_(分组)=5.386,P<0.05),两组ADL评分随着时间的延长表现出逐渐下降的趋势(F_(时间)=12.468,P<0.05),观察组下降的幅度大于对照组(F_(交互)=3.731,P<0.05)。结论养血醒脑方可有效提高脑卒中后精神障碍疗效,对认知功能、行为能力有积极影响。
Objective To observe the effects of Yangxue Xingnao decoction （YXD） on efficacy of cognitive function,behavior ability in patients with mental disorder after stoke.Methods One hundred and sixty-six patients with mental disorder after stoke were randomly divided into the observation group （n=85） and the control group （n=81）.The patients in control group were given quetiapine,and the patients in observation group were given YXD based on the control group.After treatment of 4 weeks and follow-up from 4 months,to observe the clinical efficacy and differences of cervical erosion sample,human papillary virus infection between the two group.Treatment for 4 weeks and follow-up 4 weeks,to observe the efficacy and the differences of Mini-Mental State Exam （MMSE） score,activities of daily living scale （ADL） score.Results The cure rate of the observation group was 67.06%,the significant improvement rate was 17.64%,the improvement rate was 11.76% and the invalid rate was 2.35%,and those of the control group were 51.85%,28.40%,19.75% and 7.41%,respectively,with significantly different （P〈0.05）.There was significantly difference of MMSE score in these two groups（Fgroup=5.634,P〈0.05）,they were all showed a rising trend over time （Ftime=10.146,P〈0.05）,the reduced amplitude in observation group was greater than the control group （Finteraction=3.105,P〈0.05）;There was significantly difference of ADL score in these two groups（Fgroup=5.386,P〈0.05）,they were all showed a reducing trend over time （Ftime=12.468,P〈0.05）,the declined amplitude in observation group was greater than the control group （Finteraction=3.731,P〈0.05）.Conclusion YXD can effectively improve the efficacy of the mental disorder after stroke,and have positive influence on cognitive function and behavior ability.
出处
《中西医结合心脑血管病杂志》
2017年第13期4562-4565,共4页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
关键词
脑卒中后精神障碍
养血醒脑方
认知功能
行为能力
日常生活活动能力
the mental disorder after stroke
Yangxue Xingnao decoction
cognitive function
behavior ability
activities of daily livin
