摘要
目的探讨益生菌在轮状病毒肠炎患儿中的临床效果及对机体免疫的影响.方法取轮状病毒肠炎患儿90例,电脑随机法分为2组.对照组采用免疫球蛋白治疗,观察组采用益生菌治疗,采用流式细胞仪检测2组治疗前、后T淋巴细胞亚群水平,比较2组临床效果及对机体免疫的影响.结果观察组治疗7 d后止泻时间(2.43 d±0.49 d)、止吐时间(1.379 d±0.24 d),、退热时间(1.429 d±0.47 d)及住院时间(3.219 d±1.02 d),均短于对照组(t=20.53、18.99、22.15、19.35,P<0.05);2组治疗前免疫水平比较差异无统计学意义(P>0.05);观察组治疗后与对照组相比,CD3^+(67.42±10.92 vs 58.51±11.24)、CD4^+(36.43±6.32 vs 32.41±5.46)及CD4^+/CD8^+(1.43±0.3 vs 1.21±0.32)水平,均高于对照组(P<0.05);观察组治疗后CD8+水平,低于对照组(23.41±4.53 vs 27.43±4.01,P<0.05).结论轮状病毒肠炎患儿采用益生菌治疗能降低菌群紊乱和并发症发生率,而免疫球蛋白则能缩短住院时间,应根据每1例患儿情况选择合适方法治疗.
AIM To investigate the clinical effects of probiotics in children with rotavirus enteritis and the effect on immune function.METHODS Ninety patients with rotavirus enteritis were randomly divided into either a control group or an observation group.The control group was treated with immunoglobulins.The observation group was treated with probiotics.The levels of T lymphocyte subsets were measured by flow cytometry before and after treatment.The clinical effects of the two groups were compared.RESULTS After treatment for 7 d,times to stopping diarrhea（2.43 d ± 0.49 d）,vomiting（1.379 d± 0.24 d）,and fever（1.429 d ± 0.47 d） and hospitalization time（3.219 d ± 1.02 d） were significantly shorter in the observation group than in the control group（t = 20.53,18.99,22.15,19.35,P〈0.05）;the levels of CD3~＋ T cells（67.42± 10.92 vs 58.51 ± 11.24）,CD4~＋ T cells（36.43 ±6.32 vs 32.41 ± 5.46） and CD4~＋/CD8~＋ ratio（1.43± 0.3 vs 1.21 ± 0.32） were significantly higher in the observation group than in the control group（P〈0.05）,but the level of CD8~＋ T cells in the observation group was significantly lower than that in the control group（23.41±4.53 vs 27.43＋4.01,P〈0.05）.CONCLUSION The use of probiotics in children with rotavirus enteritis can reduce the incidence of microflora dysfunction and complications.Immunoglobulins can shorten the hospitalization time and should be selected according to the situation of each patient.
出处
《世界华人消化杂志》
CAS
2017年第18期1684-1687,共4页
World Chinese Journal of Digestology
