摘要
目的观察乌梅降糖止泻方对上热下寒型糖尿病伴顽固腹泻患者的临床疗效及胃肠动力指标变化。方法选取2014年10月—2016年12月深圳市中医院收治的271例上热下寒型糖尿病伴顽固腹泻患者,采用随机平行对照法分为对照1组91例、对照2组90例和观察组90例。3组均给予严格控制血糖的基础治疗,对照1组不辅以其他治疗,对照2组辅以蒙脱石散治疗,观察组辅以乌梅降糖止泻方治疗,疗程均为1个月。疗程结束后评价3组治疗后胃肠道症状积分、临床疗效、血糖水平、胃肠动力指标变化情况及用药安全性。结果治疗后观察组6项胃肠道症状积分均较治疗前显著改善,且各项症状积分较对照1组、对照2组治疗后均改善(P<0.05)。治疗后观察组总有效率为90.00%,显著高于对照1组的32.97%和对照2组的73.33%(P<0.05)。3组治疗后空腹血糖、餐后2 h血糖、糖化血红蛋白水平均优于治疗前(P<0.05),治疗后观察组上述指标水平均优于对照1组和对照2组(P<0.05)。治疗后,对照2组、观察组口-结肠转运时间、生长抑素、胃动素、胃泌素水平与治疗前比较差异均有统计学意义(P<0.05);观察组治疗后上述胃肠动力指标水平均优于对照1组和对照2组(P<0.05)。观察组在治疗期间无明显药物不良反应。结论乌梅降糖止泻方辅助治疗上热下寒型糖尿病伴顽固腹泻,可明显改善患者腹泻、多项胃肠道症状及胃肠道功能,降低基础血糖,且不良反应少,患者依从性好。
Objective To observe effectiveness of smoked plum hypoglycemic antidiarrheal and effect on gastrointestinal function index in adjunctive therapy of patients with heat-syndrome in the upper part but cold in the lower diabetes mellitus complicated by intractable diarrhea.Methods A total of 271 patients with heat-syndrome in the upper part but cold in the lower diabetes mellitus complicated by intractable diarrhea admitted during October 2014 and December 2016 were randomly divided into blank control group（n=91）, drug control group （n=90） and observation group （n=90） by random parallel control method.All patients received basic treatment of strict control of blood sugar.Blank control group was not treated with other treatments, and drug control group was treated with Smectite Powder, and observation group was given smoked plum hypoglycemic antidiarrheal treatment.The course of treatment was 1 month.After treatment, gastrointestinal symptoms scores, clinical effectiveness, blood glucose level and changes of gastrointestinal motility index before and after treatment and medication safety were evaluated in the 3 groups.Results After treatment, in observation group, 6 kinds of gastrointestinal symptom scores were significantly improved compared with those before treatment, and each gastrointestinal symptom score was significantly improved compared with those after treatment in black and drug control groups （P〈0.05）.The total effective rate in observation group was 90.00%, and the rate was significantly higher than 32.97% in blank control group and 73.33% in drug control group （P〈0.05）.Values of fasting blood glucose （FBG）, 2 h postprandial blood glucose （2 h PBG） and glycosylated hemoglobin （HbA1c） levels after treatment were significantly better than those before treatment among the 3 groups （P〈0.05）, and the above indexes after treatment in observation group were better than those in blank and drug control groups （P〈0.05）.After treatment, orocecal transit time （OCTT）
出处
《临床误诊误治》
2017年第7期91-95,共5页
Clinical Misdiagnosis & Mistherapy
基金
广东省第二批名中医师承项目(粤中医办函[2015]93号)
关键词
糖尿病
糖尿病并发症
腹泻
胃肠动力学
中药方剂
乌梅
Diabetes mellitus
Diabetes complications
Diarrhea
Gastrointestinal dynamics
Chinese medicinal formulae
Prunus mume
