摘要
慢性乙型肝炎(CHB)是一世界性公共卫生问题。乙型肝炎病毒(HBV)持续性感染的关键是病毒复制环节中形成的闭合环状DNA,现有治疗措施难以将其彻底清除。研究表明,自然杀伤细胞(NK)在HBV慢性持续性感染过程中的表型和功能变化不同于急性感染,提示NK细胞的功能可能与机体能否清除HBV有关。NK细胞作为重要的天然免疫细胞,其发育、分化和活化依赖于代谢活性,哺乳动物雷帕霉素靶蛋白(m TOR)是一类与细胞代谢活性高度相关的丝氨酸/苏氨酸激酶,其磷酸化水平决定着NK细胞的代谢活性和功能。本文从HBV的慢性持续性感染、NK细胞的表型和功能、NK细胞发育分化与m TOR的关系等方面进行综述。
Chronic hepatitis B is a world-wide health problem and now at least 250 million people have been infected with hepatitis B virus. Current treatment of hepatitis B rarely achieves a cure because the viral replication template which called covalently closed circular DNA（ccc DNA） are resistant to conventional therapies. The phenotype and function of natural killer cells from chronic hepatitis B patients are different to those from acute hepatitis B patients, suggesting that the function of NK cells may be related to clearance of HBV. Some studies have suggested that the differentiation, development and activation of natural killer cells are controlled by the mammalian target of rapamycin. The present review will mainly focus on the biology of hepatitis B virus, the differentiation and development of natural killer cells, and the progress of metabolism of natural killer cells.
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2017年第7期656-660,共5页
Medical Journal of Chinese People's Liberation Army
基金
首都医学发展科研基金(2014-2-5033)~~
关键词
肝炎
乙型
慢性
自然杀伤细胞
雷帕霉素靶蛋白
hepatitis B
chronic
natural killer cells
mammalian target of rapamycin
