摘要
目的探索A型肉毒毒素联合非剥脱性1550 nm点阵激光和透明质酸改善面部皱纹和凹陷的临床疗效。方法收集2014年3月~2016年8月到我院进行除皱的114例患者,采用随机数字表法将患者分为三组:激光联合治疗组,透明质酸联合治疗组和注射对照组。激光联合治疗组先注射A型肉毒毒素,2周后用1550 nm点阵激光治疗3次,每次间隔4周;透明质酸联合治疗组先用透明质酸进行不同层次的皮下注射,再进行A型肉毒毒素注射;注射对照组只对患者进行A型肉毒毒素注射。治疗后应用VISIA皮肤测试仪评价治疗效果,记录患者4、12、24周后的面部情况。结果三组患者治疗前后的VISIA评分差异均有统计学意义(P<0.05)。透明质酸联合治疗组治疗后的VISIA评分与注射对照组差异有统计学意义(P=0.037),激光联合治疗组与注射对照组的VISIA评分差异无统计学意义(P=0.758)。术后第4、12、24周,透明质酸联合治疗组(92.1%、86.8%、78.9%)与注射对照组(86.8%、81.6%、71.1%)的有效率差异均有统计学意义,激光联合治疗组(86.8%、81.6%)与注射对照组(81.6%、71.1%)在术后第12、24周的有效率差异有统计学意义(P<0.05)。结论 A型肉毒毒素能安全有效地减轻脸部皱纹,其与点阵激光和透明质酸联合使用能使除皱效果更好,作用时间更长。
Objective To explore the clinical efficacy of botulinum toxin type A combined with non stripped 1550 nm dot matrix laser and Hyaluronic Acid improving facial wrinkles.Methods 114 patients given wrinkle removal in our hospital from March 2014 to August 2016 were collected and they were divided into the three groups according to the random number table method：laser combined treatment group,Hyaluronic Acid combined treatment group and injection control group.The laser treatment group was injected with botulinum toxin type A and given 1550 nm dot matrix laser of three times after 2 weeks,each time had a interval of 4 weeks.Hyaluronic Acid combined treatment group was treated with different levels of subcutaneous injection of Hyaluronic Acid,then botulinum toxin type A was injected.The injection control group was only injected botulinum toxin A.VISIA skin tester was used to evaluate the treatment effect and facial state of patients was recorded after 4,12,24 weeks.Results The difference of VISIA score among the three groups before and after treatment was statistically significant （P〈0.05）.There was a statistical difference of VISIA score between the Hyaluronic Acid combined treatment group and injection control group （P=0.037）,and there was no statistical difference of VISIA score between the laser combined treatment group and injection control group （P=0.758）.After 4,12,24 weeks operation,there was a statistical difference of the effective rate between the Hyaluronic Acid combined treatment group （92.1%,86.8%,78.9%） and injection control group （86.8%,81.6%,71.1%）,and there was a statistical difference of the effective rate between the Hyaluronic Acid combined treatment group （86.8%,81.6%） and injection control group （81.6%, 71.1%）（P〈0.05）.Conclusion Botulinum toxin type A can effectively and safely reduce facial wrinkles,and its effect was better combined with dot matrix laser and Hyaluronic Acid.
出处
《中国当代医药》
2017年第19期30-32,共3页
China Modern Medicine
