摘要
microRNA是能够调控靶基因表达的小分子RNA,在脊髓发育和脊髓损伤等过程的基因表达中具有重要作用,可能是促进脊髓损伤后神经再生和修复的治疗性干预新靶点,是脊髓损伤潜在的生物学标志物。本文从microRNA在脊髓损伤中的机制及热点microRNA方面做一综述。
MicroRNAs are short non-coding RNAs that regulate and control the translation of target genes, and play an important role in gene expression involved in the development of spinal cord and spinal cord injury, which constitute novel targets for therapeutic intervention to promote repair and regeneration of the spinal cord, also they are the potential biomarkers of spinal cord injury. This article reviewed the mechanism of microRNAs and listed several microRNAs in spinal cord injury area.
出处
《中国康复理论与实践》
CSCD
北大核心
2017年第6期649-653,共5页
Chinese Journal of Rehabilitation Theory and Practice
基金
国家自然科学基金面上项目(No.81272164)
中央级公益性科研院所基本科研业务费专项资金项目(No.2015CZ-6)
关键词
脊髓损伤
MICRORNA
基因表达
转录调控
生物学标记
新靶点
综述
spinal cord injury
microRNA
gene expression
transcriptional regulation
biological markers
novel targets
review
