摘要
目的:探讨丁二磺酸腺苷蛋氨酸(SAMe)联合地塞米松治疗对妊娠期肝内胆汁淤积症(ICP)患者肝功能及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-12(IL-12)水平的影响。方法:选取我院2014年10月~2016年10月收治的86例ICP患者,依据随机数字表法均分为两组。对照组予以SAMe治疗,观察组在此基础上予地塞米松治疗。记录比较两组治疗前后皮肤瘙痒评分、肝功能指标、血清TNF-α、IL-12水平,并评价两组用药安全性。结果:与治疗前对比,两组治疗7 d后皮肤瘙痒评分均显著降低(P<0.01);且观察组治疗7 d后皮肤瘙痒评分的改善效果显著优于对照组同期(P<0.01)。两组治疗7 d后血清谷草转氨酶(AST)、谷丙转氨酶(ALT)及总胆汁酸(TBA)水平均显著低于治疗前(P<0.01);与对照组同期相比,观察组治疗7 d后肝功能指标的改善程度均更为显著(P<0.01)。与治疗前相比,两组治疗7 d后血清TNF-α、IL-12水平均显著下降(P<0.01);且观察组治疗7 d后血清促炎性细胞因子水平的改善幅度均显著优于对照组同期(P<0.01)。治疗过程中,两组均未见明显不良反应/事件。结论:丁二磺酸腺苷蛋氨酸联合地塞米松治疗ICP能更有效缓解患者的皮肤瘙痒症状,改善肝功能,疗效显著,且安全性高。
Objective：To investigate the effect of S-adenosylmethionine （SAMe） combined with dexamethasone on the liver function and serum tumor necrosis factor-α （TNF-α） and interleukin-12 （1L-12） levels of patients with intrahepatic cholestasis of pregnancy （ICP）.Methods：86 cases ofICP patients admitted in our hospital from October 2014 to October2016 were selected and divided into two groups according to the random number table method.The control group was treated with SAMe,on the basis of which the observation group was treated with dexamethasone.Then the skin itching score,liver function index and serum TNF-α,IL-12 levels of the two groups before and after the treatment were compared and recorded,and the safety of medication in both groups were evaluated.Results：Compared with those before the treatment,the skin itching scores of both groups on the 7th day after treatment were significantly reduced （P〈0.01）;and the improvement effect of skin itching score of the observation group on the 7th day after treatment was significantly better than that of the control group （P〈0.01）.The serum levels ofAST,ALT and TBA in the two groups on the 7th day after treatment were significantly lower than those before the treatment （P〈0.01）;compared with those of the control group,the improvement of liver function in the observation group was more significant （P〈0.01）.Compared with those before the treatment,the serum levels of TNF-α and IL-12 on the 7th day after treatment in the two groups were significantly decreased （P〈0.01）,the improvement degree observation group were significantly better than those of the control group （P〈0.01）.In the course of treatment,there was no significant adverse reactions/events in the two groups.Conclusion：S-adenosylmethionine combined with Dexamethasone could more effectively relieve the skin itching,reduce the level of BA and improve the liver function with significant curative effect and high safetyin the treatment of ICP.
出处
《现代生物医学进展》
CAS
2017年第19期3765-3768,共4页
Progress in Modern Biomedicine
基金
四川省卫生厅科研课题(140597)
