摘要
胃肠胰神经内分泌肿瘤是一组起源于胃肠道肽能神经元和神经内分泌细胞的异质性肿瘤。直肠是胃肠胰神经内分泌肿瘤主要发病部位之一。直肠神经内分泌肿瘤(rNENs)病程进展相对缓慢,但亦可发生转移,远处转移器官主要为肝脏。外科手术是目前治疗rNENs原发病灶和肝转移病灶的首选方式,当无法行外科手术治疗时可以考虑介入治疗;rNENs的化疗和分子靶向治疗多参照胰腺神经内分泌肿瘤的用药方案,可使患者获得部分缓解或病情稳定,并延长生存时间。但目前单独针对rNENs的临床研究较少,其治疗方案尚未形成共识,因此,亟需积累大规模的循证医学证据。笔者对近年来rNENs及其肝转移治疗中出现的进展进行探讨与总结。
Gastroenteropancreatic neuroendocrine neoplasms are a group of heterogeneous tumors originated from the gastrointestinal peptidergic neurons and neuroendocrine cells. Rectum is one of the major sites of gastroenteropancreatic neuroendocrine neoplasms. Although the progression of rectal neuroendocine neoplasms (rNENs) is relatively slow, metastasis could occurs and liver is the major target organ invaded by distant metastatic rNENs. Surgical operation can be used as the preferred method for the treatment of rNENs and its metastasis at present. If the clinical situations of tumors are not eligible for the operation, interventional treatment can be considered as an alternative treatment. The chemotherapies and moleculetargeted drugs for rNENs are primarily in the light of therapeutic methods for pancreatic neuroendocrine neoplasms,it may help patients achieve partial response or stable disease, and prolong patients survival time. However, there has been few clinical researches directed toward rNENs and no an extensive consensus for treatment of rNENs up to now, and more evidences of evidence based medicine should be necessitated. This paper has discussed and summarized treatment progression of rNENs and its metastasis.
作者
毛威麟
吕洋
许雪峰
Mao Weilin Lyu Yang Xu Xuefeng.(Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, Chin)
出处
《中华消化外科杂志》
CAS
CSCD
北大核心
2017年第7期762-766,共5页
Chinese Journal of Digestive Surgery
基金
国家自然科学基金(81572294)
关键词
神经内分泌肿瘤
直肠
治疗
转移
Neuroendocrine neoplasms, rectum
Therapy
Metastases