摘要
目的探讨血清中白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)与慢性阻塞性肺疾病患者病情分级和呼吸功能的关系。方法选择2015年9月至2016年9月期间50例在该院诊断为慢性阻塞性肺疾病的患者作为观察组,并以健康体检的40例患者作为对照组,采用ELISA法检测患者血清中IL-6、TNF-α水平,采用相关性分析探讨血清中炎症因子与慢性阻塞性肺疾病(COPD)患者病情分级和呼吸功能的关系。结果观察组患者TNF-α为(4.27±0.34)μg/L、IL-6为(21.54±3.67)ng/L均明显高于健康对照组的(1.36±0.29)μg/L、(10.27±1.36)ng/L(P<0.05),不同GOLD分期COPD患者的TNF-α、IL-6水平、症状评分均有差异(P<0.05);GOLD分期越高,TNF-α、IL-6、症状评分越高,两两比较差异均有统计学意义(P<0.05)。TNF-α、IL-6与症状评分、肺功能、GOLD分级呈正相关(P<0.05)。结论血清中TNF-α、IL-6水平与COPD患者病情、肺功能呈正相关。
Objective To investigate the relationship between serum TNF-αand IL-6levels and respiratory function in patients with chronic obstructive pulmonary diseases.Methods 50 cases in our hospital diagnosed as chronic obstructive pulmonary disease from September 2015 to September 2016 were selected as the observation group,and 40 cases of healthy people were enrolled as the control group,serum IL-6,TNF-αwere detected by ELISA in those people,correlation analysis was used to explore the relation ship between serum inflammatory factors,grading of disease and respiratory function in patients with chronic obstructive pulmonary disease(COPD).Results In the observation group TNF-α[(4.27±0.34)μg/L],IL-6[(21.54±3.67)ng/L]were significantly higher than those in healthy control group[(1.36±0.29)μg/L,(10.27±1.36)ng/L],the difference were statistically significant(P<0.05).COPD patients in different GOLD stage differed in the serum contents of TNF-α,IL-6and symptom score(P<0.05).The serum contents of TNF-α,IL-6 and symptom score were higher when the GOLD stage got higher.TNF-α,IL-6was positively correlated with symptom score,lung function,GOLD classification(P<0.05).Conclusion Serum levels of TNF-α,IL-6and COPD are positively correlated with the patient′s condition,and positive correlation with pulmonary function.
出处
《国际检验医学杂志》
CAS
2017年第13期1781-1783,共3页
International Journal of Laboratory Medicine
关键词
慢性阻塞性肺疾病
炎症因子
肺功能
病情
chronic obstructive pulmonary disease
inflammatory factor
pulmonary function
condition
