摘要
血管平滑肌细胞上大电导钙激活钾通道(BK_(Ca))在血管舒缩和血压调节中发挥了重要作用。其激活导致细胞膜超极化,从而引起血管平滑肌舒张。但在糖尿病或高糖状态下,BK_(Ca)功能受损,其对血管紧张性的调节作用降低,这可能是糖尿病患者心脑血管疾病发生的重要机制。近年来,泛素蛋白酶途径、肾素-血管紧张素系统信号通路对BK_(Ca)尤其是β_1亚单位的影响越来越受关注。因此,BK_(Ca)尤其是β_1亚单位及其调节途径中涉及的关键分子,有望成为治疗糖尿病引起的心脑血管病变的重要靶点。
Large conductance calcium-activated potassium channels（BK_（Ca））,abundantly expressed in vascular smooth muscle cells,play an important role in vasodilation and regulation of blood pressure. Activation of BK_（Ca）channels leads to the hyperpolarization of the plasma membrane,which eventually contributes to the vasodilation. Under the circumstance of diabetes or high blood glucose,BK_（Ca）channels are damaged,resulting in the losing of regulation function that the BK_（Ca）channels act on the vascular tone,which might be an important mechanism of cardiovascular and cerebrovascular diseases of diabetic patients. In recent years,the effects of ubiquitin-proteasome pathway and rennin-angiotensin system signal path on the BK_（Ca） channel,especially the β_1 subunit,have drawn more and more attention. Therefore,BK_（Ca）channels,especially the β_1 subunit,and the key molecules involved in the regulatory pathway,are expected to become the important targets to treat cardiac cerebrovascular diseases caused by diabetes.
出处
《医学综述》
2017年第12期2414-2418,共5页
Medical Recapitulate
基金
国家自然科学基金(31371162
31671190)
北京市教育委员会科技发展计划项目(KM201710025004)
关键词
糖尿病
大电导钙激活钾通道
血管平滑肌细胞
舒张功能障碍
Diabetes mellitus
Large conductance calcium-activated potassium channels
Vascular smooth muscle cells
Diastolic dysfunction
