摘要
背景:骨髓间充质干细胞可能对年龄相关疾病敏感,是影响退行性疾病骨重建的重要因素之一。目的:综述骨髓间充质干细胞的衰老特征及治疗进展。方法:检索Pub Med数据库2006年6月至2016年6月关于骨髓间充质干细胞衰老及治疗的相关文章,以"MSCs,aging"为关键词进行检索,排除陈旧性和无关研究,最终选择关于骨髓间充质干细胞衰老及治疗的61篇文献,并参考《哈德兹老年医学》进行综述。结果与结论:骨髓来源间充质干细胞可支持免疫和造血系统中的造血祖细胞生长,促进骨髓组织修复,影响骨的生长和重建,其也会随着年龄及其他因素发生老化,进而影响其功能。衰老的骨髓间充质干细胞表现出端粒缩短、增殖和分化能力减弱、氧化应激水平增高等特点。目前研究可通过调节端粒酶活性,干预氧化应激或微环境中的Wnt/β-catenin等信号通路,应用p16、p53等基因表达或组蛋白乙酰转移酶、溶血磷脂酸等药物,以及通过机械力、能量限制等非药物手段来延缓或防止骨髓间充质干细胞的衰老,提高其临床疗效,但更确切的机制尚待进一步研究。
BACKGROUND： Bone marrow mesenchymal stem cells may be sensitive to age-related diseases, which is a contributory factor of bone remodeling after degenerative diseases. OBJECTIVE： To summarize the features of aging and progress in treatments related to cell aging. METHODS： We retrieved PubMed database for articles concerning aging of bone marrow mesenchymal stem cells and its treatments published from June 2006 to June 2016. The key words were ＂MSCs, aging＂. Finally, 61 relevant articles were selected and reviewed in reference with Hazzard＇s Geriatric Medicine and Gerontology. RESULTS AND CONCLUSION： Bone marrow derived mesenchymal stem cells can support the growth of hematopoietic progenitor cells in the immune and hematopoietic system, promote repair of the bone marrow, and influence bone growth and remodeling. However, cell aging occurs with age and other factors will affect cell function. Aging bone marrow mesenchymal stem cells show shortened telomere, reduced proliferation and differentiation ability and increased oxidative stress level. Current evidence has confirmed that cell aging can be delayed or prevented by adjustment of age-related telomerase activities, oxidative stress intervention, Wnt/beta-catenin signaling pathway in the microenvironment, regulation of p16, p53 gene expression or drugs such as histone acetyltransferase and lysophosphatidic acid, thereby to improve the clinical curative effect of bone marrow mesenchymal stem cells. However, the exact mechanism remains to be further studied.
作者
陈裕浩
朱向情
潘兴华
Chen Yu-hao Zhu Xiang-qing Pan Xing-hua(Cell Biological Therapy Center of Kunming General Hospital of Chengdu Military Area of Chinese PLA, National and Regional Integrated Engineering Laboratory of Stem Cells and Immunocyte Biological Technology, Stem Cell Engineering Laboratory of Yunnan Province, Key Laboratory of Stem Cells and Regenerative Medicine of Kunming City, Kunming 650032, Yunnan Province, China Guizhou Medical University, Guiyang 550025, Guizhou Province, China)
出处
《中国组织工程研究》
CAS
北大核心
2017年第17期2746-2752,共7页
Chinese Journal of Tissue Engineering Research
基金
国家支持项目(2014BIO1B01)
昆明市重点项目(2015-1-S-00973)~~
