摘要
目的:分析替吉奥联合奥沙利铂及多西他赛对姑息切除胃癌患者术后疗效。方法:收集某院资料完整的姑息切除胃癌患者83例,根据患者接受治疗方案不同分为2组。替吉奥联合奥沙利铂及多西他赛组(治疗组,42例):术后25 d左右开始替吉奥联合奥沙利铂及多西他赛化疗。多西他赛联合奥沙利铂、氟尿嘧啶的单纯化疗组(对照组,41例)。2组患者一个疗程均21 d,并在3个疗程后检查评估各组化疗效果及毒性反应。结果:有效率和疾病控制率治疗组患者为68.4%和86.8%,显著高于对照组43.6%和61.5%。不良反应骨髓抑制、口腔溃疡、恶心呕吐、手足综合征等发生率治疗组患者显著低于对照组。结论:替吉奥联合奥沙利铂及多西他赛化疗对晚期姑息切除胃癌患者不仅有较好的疗效,不良反应发生率较低,且无较严重不良反应。治疗效果优于多西他赛联合奥沙利铂及氟尿嘧啶的单纯化疗方案。
Objective：To evaluate the clinical efficacy and safety of S-l, oxaliplatin and docetaxel chemotherapy combined with palliative surgery in treatment of patients with gastric cancer. Methods ： 83 cases of gastric cancer with different treatments were retrospectively analyzed. The patients were divided into 2 groups according to different regimens：the S-1, oxaliplatin and docetaxel chemotherapy treatment group （treatment group, 42 cases ） , and the fluorouracil, oxaliplatin and doeetaxel chemotherapy treatment group （control group,41 cases）. Chemotheraphy was given about 25 clays after operation. The cycle was repeated every 21 days. Clinical efficacy and toxicity were observed after 3 cycles. Results：The clinical effective rate and disease control rate （68.4% ; 86.8% ） of the treatment group were significantly higher than those of the control group （ 43.6% ; 61.5 % , P 〈 0.05 ）. The incidence of adverse reactions such as myelosuppression, dental ulcer, hand-foot syndrome, nausea and vomiting of the treatment group was significantly lower than that of the control group. Conclusion：The regimen of palliative surgery combined with S-1, oxalip]atin and docetaxel chemotherapy in treatment of gastric cancer shows high clinical efficacy and less toxicity.
出处
《淮海医药》
CAS
2017年第4期407-409,共3页
Journal of Huaihai Medicine
