摘要
目的探讨无创正压通气治疗稳定期慢性阻塞性肺疾病(COPD)合并慢性II型呼吸衰竭患者的疗效。方法将2015年2月~2016年3月72例稳定期COPD合并慢性呼吸衰竭患者随机分为对照组与实验组,每组36例。对照组采用经鼻导管吸氧,实验组采用氧疗+BiPAP呼吸机行无创正压通气治疗。比较两组血气分析指标、心率和呼吸频率。结果通气治疗后实验组PaCO_2为(54.93±1.86)mm Hg、p H为(7.38±0.03),较对照组的(63.82±2.30)mm Hg、(7.28±0.04)改善更佳(P<0.05);两组PaO_2、SaO_2差异不大。治疗后两组急性加重次数与6min步行距离均有显著改善(P<0.05);治疗后实验组急性加重次数与6min步行试验结果较对照组明显改善(P<0.05)。结论无创正压通气治疗稳定期COPD合并慢性Ⅱ型呼吸衰竭患者效果良好,可及时改善患者通气,缓解呼吸肌疲劳减少机体耗氧量,增加活动耐力,以及减少急性加重次数,具有积极的临床意义。
Objective Toexplore the curative effect of noninvasive positive pressure ventilation in treatment of patients with stable chronic obstructive pulmonary disease（COPD） complicated with chronic type Ⅱ respiratory failure. Methods 72 patients with stable COPD complicated with chronic type Ⅱ respiratory failure from February 2015 to 2016 March were randomly divided into the control group and the experimental group,with 36 in each group.The control group was given nasal tube of oxygen inhalation while the experimental group was treated with noninvasive positive pressure ventilation by oxygen therapy combined with BaPAP ventilator.Blood gas analysis index, heart rate and respiratory rate of two groups were compared. Results After ventilation treatment,PaCO2 and pH of the experimental group was（54.93±1.86） mm Hg and （7.38±0.03） respectively,better than those of the control group （63.82±2.30） mm Hg and （7.28±0.04）.There was no significant difference in PaO2 and SaO2 be tween two groups： After treatment,times of aeutc exacerbation and 6-minute walking distance in two groups were both significgntly improved（P〈 0.05）.After treatment,times of acute exacerbation and 6-minute walking distance of the experimental group were more significantly improved than those of the control group（P 〈 0.05）. Conclusion Noninvasive positive press,re ventilation in treatment of patients with stable COPD complicated with chronic type Ⅱ respiratory failure has a good effect. It can timely improve ventilation of patients,relieve respiratory muscle fatigue,reduce body oxygen consumption,increase activity endurance and reduce times of acute exacerbation,which is worthy of positive clinical significance.
作者
孔沛良
江宏志
张平
KONG Peiliang JIANG Hongzhi ZHANG Ping(Department of Respiratory Medicine,Dongguan People＇s Hospital,Dongguan 523059,Chin)
出处
《中国医药科学》
2017年第9期242-244,共3页
China Medicine And Pharmacy
关键词
慢性阻塞性肺疾病
Ⅱ型呼吸衰竭
无创正通气
稳定期
Chronic obstructive pulmonary disease
Type Ⅱ respiratory failure
Noninvasive positive pressure ventilation
Stable
