摘要
目的探讨结直肠癌肺转移患者的临床特征及预后生存分析。方法选取2008年1月至2014年1月间福建医科大学附属第一医院收治的146例结直肠癌肺转移患者的临床资料及随访资料,分析患者的临床特征及影响结直肠癌肺转移患者预后的相关因素。结果患者中位随访时间为35.1个月,中位生存时间为27.1个月,1年、3年和5年生存率分别为75.3%、30.8%和12.4%。病理组织分级、TNM肿瘤分期、肺转移灶大小、肺转移灶数目、是否合并肝转移和治疗方式不同的结直肠癌肺转移患者,预后生存时间差异均有统计学意义(均P<0.05)。低分化结直肠癌、高TNM分期、合并肝转移及单纯化疗是影响结直肠癌肺转移患者预后生存的独立危险因素,差异有统计学意义(P<0.001)。结论结直肠癌肺转移患者预后较差,低分化、高TNM分期、合并肝转移及单纯化疗是影响患者预后生存的危险因素,积极进行综合治疗可提高预后疗效。
Objective To investigate the clinical features and prognosis in patients with lung metastasis form colorectal cancer. Methods The clinical data and follow-up data of 146 patients with lung metastases from colorectal cancer treated at The First Affiliated Hospital of Fujian Medical University from January 2008 to January 2014 were collected. The clinical characteristics and the related factors influencing the prognosis in patients with lung metastasis from colorectal cancer were analyzed. Results Over the median follow-up of 35. 1 months,the median survival time was 27. 1 months and 1-,3-and 5-year survival rate was75. 3%,30. 8% and 12. 4%,respectively. There were statistically significant differences in survival time among patients with different histological grade,TNM stage,size and number of metastatic tumors,complicated with liver metastasis and treatments（all P〈0. 05）. Low differentiation of colorectal cancer,high TNM staging,complicated with liver metastasis and chemotherapy were independent risk factors influencing the prognosis in patients with lung metastasis from colorectal cancer（P〈0. 01）. Conclusion The prognosis of patients with lung metastasis from colorectal cancer is poor. Low differentiation of colorectal cancer,high TNM staging,complicated with liver metastasis and chemotherapy were independent risk factors influencing the prognosis. Active and comprehensive treatment can improve the prognosis of patients.
出处
《中国肿瘤临床与康复》
2017年第6期718-721,共4页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
结直肠肿瘤
肺转移
临床特征
预后
Colorectal neoplasms
Lung metastasis
Clinical features
Prognosis
