摘要
目的 采用meta分析方法评价目标导向液体治疗（GDFT）对腹部手术后转归的影响。方法 检索Pubmed、Embase、CINAHAL、Scopus和Cochrane图书馆中自1980年至2016年5月的文献，GDFT作为治疗组，常规液体治疗作为对照组；主要指标为术后死亡率、术后并发症的发生率、住院时间，次要指标为胃肠功能恢复情况。采用RevMan 5.1和Stata 12.0软件进行meta分析。结果 共纳入45个随机对照试验，包括6344例患者，治疗组3406例，对照组2938例。meta分析结果显示：与对照组相比，治疗组患者出现术后并发症的人数减少，住院时间缩短，术后第1次排气时间和术后第1次可进食时间缩短（P〈0.05）。2组术后死亡率差异无统计学意义（P〉0.05）。结论 GDFT可促进腹部手术后转归，对患者生存率无影响。
Objective To systematically review the effect of goal-directed fluid therapy（GDFT）on outcomes following abdominal surgery.Methods Pubmed, Embase, CINAHAL, Scopus and Cochrane Library were searched from 1980 to May 2016 to identify randomized controlled trials involving the effect of GDFT on outcomes following abdominal surgery in adults（aged〉18 yr）. GDFT served as therapy group, and conventional fluid therapy served as control group.The major evaluation indexes included the postoperative mortality rate, incidence of postoperative complications and length of hospital stay.The secondary evaluation index was the recovery of postoperative gastrointestinal function.Meta-analysis was conducted using the RevMan 5.1 and Stata 12.0 softwares.Results Forty-five randomized controlled trials involving 6344 patients were included in our meta-analysis, and there were 3406 cases in therapy group and 2938 cases in control group.The results of meta-analysis showed that compared with control group, the number of patients who developed postoperative complications was significantly decreased, the length of hospital stay was shortened, and the time to first flatus and time to first liquid diet were shortened in therapy group（P〈0.05）. There was no significant difference in the mortality rate between the two groups（P〉0.05）.ConclusionGDFT can promote outcomes following abdominal surgery and exerts no effects on the survival rate in patients.
出处
《中华麻醉学杂志》
CSCD
北大核心
2017年第5期558-564,共7页
Chinese Journal of Anesthesiology
关键词
补液疗法
腹部
外科学
预后
Fluid therapy
Abdomen, surgery
Prognosis
