摘要
目的检测慢性心力衰竭(CHF)患者血清中期因子(MK)水平,探讨其临床价值。方法收集CHF患者91例,按照纽约心脏协会(NYHA)心功能分级标准进行分级,其中心功能Ι级22例、Ⅱ级24例、Ⅲ级25例、Ⅳ级20例,同期正常健康体检者血清标本30例,采用酶联免疫吸附(ELISA)法测定血清标本中的MK水平。随访1年,终点事件为全因死亡。结果 CHF患者组血清MK平均水平高于对照组,差异有统计学意义(P<0.05);随着心功能分级增加,血清MK水平逐级升高,各组之间差异有统计学意义(P<0.05);随访1年,死亡组血清MK水平高于非死亡组,差异有统计学意义(P<0.05)。结论血清MK水平能准确、有效地对CHF患者进行诊断,反映心力衰竭的严重程度。高水平的MK预示未来1年心衰患者发生死亡的风险将显著增加。
Objective To investigate the serum midkine（MK） level and explore its clinical significance in patients with chronic heart failure（CHF）. Methods 91 chronic heart failure（CHF） patients were divided into grade I cardiac function group（group I, n = 22）, grade H cardiac function group（ group Ⅱ, n = 24）, grade m cardiac function group（ group Ⅲ, n = 25） and grade 1V cardiac function group（ group IV, n = 20） according to the cardiac function grading recommended by NYHA, and 30 controls were collected. The serum level of midkine was measured by using enzymelinked immunoadsobent assay（ELISA）. The patients were followed up for one year, and the primary endpoint was defined as all - cause death. Resul.ts The average level of mid- kine in serum of patients with CHF was significantly higher than the cases of controls, with the differences statistically significant （P 〈 O. 05 ） ; with the increase of cardiac function classification, the serum MK levels gradually increased, with the differences among the groups statistically significant（P 〈 O. 05） ; and the level of midkine in death group was significantly higher than the group of non - death after followed - up one year, with the differences statistically significant （P 〈 0.05）. Conclusion The se- rum MK level can accurately and effectively diagnose the CHF patients, and reflect the severity of heart failure. High levels of MK predict that the risk of death in oatients with heart failure will significantly increase in the coming year.
出处
《中国卫生检验杂志》
CAS
2017年第12期1731-1733,共3页
Chinese Journal of Health Laboratory Technology
基金
浙江省自然科学青年基金项目(LQ13H160019)
关键词
慢性心力衰竭
中期因子
酶联免疫吸附法
心功能分级
Chronic heart failure
Midkine
Enzymelinked immunoadsobent assay
Cardiac function group
