急性一氧化碳中毒患者病情评估的相关风险因素分析被引量：3

Analysis of Related Risk Factors in Assessment of Acute Carbon Monoxide Poisoning Patients

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摘要目的:分析与研究急性一氧化碳中毒患者病情评估的相关风险因素。方法:选取2012年1月-2016年2月本院收治的116例急性一氧化碳中毒患者为研究对象,根据中毒严重程度分为轻中度中毒组72例和重度中毒组44例,比较两组患者的乳酸水平、APACHEⅡ评分、昏迷时间、碳氧血红蛋白百分比、心肌酶、肌钙蛋白、白介素-6(IL-6)及迟发性脑病发生率,并采用多因素Logistic回归分析检验上述因素与急性一氧化碳中毒预后的关系,相关性采用Pearson相关分析。结果:重度中毒组的乳酸水平、APACHEⅡ评分、碳氧血红蛋白百分比、心肌酶、肌钙蛋白、IL-6及迟发性脑病发生率均高于轻中度中毒组,昏迷时间长于轻中度中毒组,差异均有统计学意义(P<0.01),且多因素Logistic回归分析显示,乳酸水平、APACHEⅡ评分、昏迷时间、碳氧血红蛋白百分比、心肌酶、肌钙蛋白、IL-6及迟发性脑病发生率均是急性一氧化碳中毒预后的危险因素(P<0.05),上述指标均与一氧化碳病情均呈正相关(P<0.05)。结论:急性一氧化碳中毒患者的病情严重,且影响患者预后的相关因素较多,对患者救治的过程中应根据这些因素进行针对性干预。 Objective：To analyze and study the risk factors associated with the assessment of patients with acute carbon monoxide poisoning.Method：116 patients with acute carbon monoxide poisoning in our hospital from January 2012 to February 2016 were selected as the study objects,and they were divided into mild to moderate poisoning group 72 cases and severe poisoning group 46 cases according to the severity of poisoning,the lactic acid level,APACHEⅡ score,coma time,the percentage of carboxyhemoglobin,myocardial enzyme,troponin,interleukin-6（IL-6） and delayed encephalopathy rate of two groups were compared,then the relationship between those factors and prognosis of acute carbon monoxide poisoning were analyzed with multivariate Logistic regression analysis,the correlation were analyzed with Pearson correlation analysis.Result：The lactic acid level,APACHEⅡ score,the percentage of carboxyhemoglobin,myocardial enzyme,troponin,IL-6 and delayed encephalopathy rate of severe poisoning group were all higher than those of mild to moderate poisoning group,the coma time was longer than that of mild to moderate poisoning group,the differences were statistically significant（P〈0.01）,the multivariate Logistic regression analysis showed lactic acid level,APACHEⅡ score,coma time,the percentage of carboxyhemoglobin,myocardial enzyme,troponin,IL-6 and delayed encephalopathy rate were the risk factors of prognosis of acute carbon monoxide poisoning（P〈0.05）,and those indexes all show positive correlation to the acute carbon monoxide poisoning（P〈0.05）.Conclusion：The disease assessment of patients with acute carbon monoxide poisoning is serious,and affect the prognosis of patients with more factors,so they should be given to targeted intervention according to the factors in the course of treatment.