摘要
目的研究在麻醉诱导前静脉泵注右美托咪定对瑞芬太尼全身麻醉(全麻)术后痛觉过敏的影响。方法将110例需要全麻手术患者随机分组,观察组麻醉诱导前进行右美托咪定静脉泵注,对照组进行常规麻醉诱导,记录术后清醒拔管时间、Ramasay评分、术后24h内VAS评分、各项生命体征和不良反应。结果观察组的不良反应率明显低于对照组(P<0.05),拔管时间、Ramsay评分差异无统计学意义(P>0.05);两组患者心率、氧分压、MAP均在正常范围内;观察组术后8h内疼痛感明显低于对照组(P<0.05),12~24h差异无统计学意义(P>0.05)。结论在麻醉诱导前泵注右美托咪定能显著缓解瑞芬太尼全麻术后痛觉过敏,安全有效,值得推广。
Objective To study the influence of intravenous pump injection of dexmedetomidine before anesthetic induction on hyperalgesia after remifentanil general anesthesia operation.Methods One hundred and ten patients needing general anesthetic surgery were randomly grouped.The observation group was given the intravenous pump injection of dexmedetomidine before anesthetic induction,while the control group conducted the routine anesthetic induction.The postoperative awakening extubation time,postoperative Ramasay score,postoperative 24 hVAS score,vital signs and adverse reactions were recorded.Results The adverse reaction rate in the observation group was significantly lower than that in the control group（P〉0.05）;the extubation time and Ramsay score had no statistically significant difference（P〈0.05）;the heart rate,oxygen partial pressure and MAP of the two groups were within the normal range;the pain sensation within postoperative 8hin the observation group was significantly lower than that in the control group（P〈0.05）,the difference at 12-24 hhad no statistical significance（P〉0.05）.Conclusion Pump injection of dexmedetomidine before anesthetic induction can significantly relieve hyperalgesia after remifentanil general anesthesia surgery,is safe,effective and worthy of promotion.
出处
《检验医学与临床》
CAS
2017年第12期1754-1755,1758,共3页
Laboratory Medicine and Clinic
