摘要
目的 观察半夏泻心汤治疗幽门螺杆菌（Hp）感染十二指肠溃疡的临床疗效及其对白细胞介素6（IL-6）的影响.方法 回顾性分析80例符合入组标准的十二指肠溃疡患者的临床资料,经快速尿素酶法检测Hp阳性,根据治疗方法不同将患者分为观察组40例和对照组40例,对照组给予三联疗法（奥美拉唑、克拉霉素、阿莫西林）治疗,观察组在对照组的基础口服半夏泻心汤,14 d为1个疗程.治疗前后进行Hp检测,统计Hp根除率;进行胃脘灼痛、嗳气吞酸、口干和四肢不温等症状评分;空腹抽血5 mL,采用放射免疫法检测IL-6;比较两组临床疗效.结果 观察组Hp根除率为85%,明显高于对照组的55%,差异有统计学意义（χ2=8.571,P〈0.05）;观察组总有效率为95%,明显高于对照组的75%,差异有统计学意义（Z=-3.143,P〈0.05）.观察组和对照组治疗后胃脘灼痛、嗳气吞酸、口干和四肢不温评分均较治疗前明显下降（t=7.167和5.664、6.919和5.713、7.462和5.051、7.372和5.136,均P〈0.05）,观察组治疗后胃脘灼痛、嗳气吞酸、口干和四肢不温评分均明显低于对照组（t=4.501、4.464、4.388、4.506,均P〈0.01）.观察组和对照组治疗后IL-6分别为（184.3±92.2）pg/mL和（283.6±102.8）pg/mL,均较治疗前明显下降（t=14.332、6.325,P〈0.05）,观察组治疗后IL-6明显低于对照组（t=7.254,P〈0.05）.结论 半夏泻心汤能够提高三联疗法治疗Hp感染十二指肠溃疡的临床疗效,有效地改善临床症状,提高Hp根除率,抑制局部炎性因子,从而减轻黏膜损伤.
Objective To observe the effect of Banxie Xiexin decoction in the treatment of duodenum ulcer complicating HP infection and its influence on IL-6.Methods Retrospective analysis of 80 patients with duodenum ulcer complicating HP infection were conducted.The patients were tested by rapid urease test for Hp infection.All the patients were randomly divided into observation group （40 cases） and control group（40 cases） according to random number table generated by SPSS19.0.The control group was treated with triple therapy（omeprazole,clarithromycin,amoxicillin）.The observation group was given Banxie Xiexin decoction on the basis of the control group,14d as a course.Before and after treatment,the Hp eradication rate was calculated.The epigastric burning,belching tunsuan,dry mouth and limbs without temperature score were measured.5mL fasting blood was exsanguinated to test IL-6.The clinical efficacy was compared.Results The eradication rate of Hp in the observation group was 85%,which was significantly higher than that in the control group（55%）.The difference was statistically significant（χ2=8.571,P〈0.05）.The total effective rate of the observation group was 95%,which was significantly higher than that of the control group（75%）.The difference was statistically significant（Z=-3.143,P〈0.05）.The epigastric burning,belching tunsuan,dry mouth and limbs without temperature score of the observation group and the control group after treatment were lower than before treatment（t=7.167 and 5.664,6.919 and 5.713,7.462 and 5.051,7.372 and 5.136,all P〈0.05）,which of the observation group after treatment were lower than those of the control group（t=4.501,4.464,4.388,4.506,all P〈0.01）.The IL-6 levels of the observation group and the control group after treatment were （184.3±92.2）pg/mL and （283.6±102.8）pg/mL respectively,which were significantly lower than before treatment（t=14.332,6.325,all P〈0.05）.The IL-6 level of the observation group after treatment was significantly lower
作者
叶邦梅
张燕玲
Ye Bangmei Zhang Yanling(Department of Pharnuwy ,the People＇s Hospital of Songyang County, Zhejiang 323400, China （ Ye BM Department of Gastroenterology, the People＇s Hospital of Songyang County, Zhejiang 323400, China （ Zhang YL)
出处
《中国基层医药》
CAS
2017年第13期2010-2014,共5页
Chinese Journal of Primary Medicine and Pharmacy
