摘要
蛋白质精氨酸甲基转移酶(PRMT)能甲基化多种蛋白,包括组蛋白和非组蛋白,影响多种细胞过程,如转录、RNA剪接、DNA修复、细胞周期的控制等。PRMT的活性受多种调节机制影响,它的异常表达在疾病的发生发展中起重要作用,尤其是肿瘤,如乳腺癌、白血病等。PRMT在肿瘤诊断或治疗中有着独特的价值。随着PRMT甲基化机制的深入探索,目前PRMT选择性抑制剂的研究已取得一定进展,PRMT特异性抑制剂有望成为治疗肿瘤的精准靶向药物。
Protein arginine methyltransferase （PRMT） can methylate a variety of proteins, including histones and non-histones, affecting a variety of cellular processes such as transcription, RNA splicing, DNA repair, and cell cycle control. The activity of PRMT is affected by a variety of regulatory mechanisms, and its abnormal expression plays an important role in the development of the diseases, especially in tumors such as breast cancer and leukemia. PRMT has a unique value in the diagnosis or treatment of tumors. With the further exploration of PRMT methylation mechanism, PRMT selective inhibitors have made some progress. PRMT-specific inhibitors are expected to be targeted drugs for the treatment of tumors.
出处
《上海交通大学学报（医学版）》
CSCD
北大核心
2017年第6期842-846,共5页
Journal of Shanghai Jiao tong University:Medical Science
基金
国家自然科学基金(81372195
81572719)
上海市教育委员会高峰高原学科建设计划(20152516)~~
