摘要
目的 探讨我国新疆和西藏地区居民体重指数、腰围与10年冠状动脉粥样硬化性心脏病(冠心病)发病风险的关系。方法 采用多阶段分层随机抽样的方法,于2015年6月至2017年3月共抽取新疆和西藏地区≥35岁研究对象7 631例,其中资料完整的5 737例纳入分析。体重指数分为3个等级组:A组<24 kg/m^2(2 005例)、B组24~〈28 kg/m^2(2 178例)、C组≥28 kg/m^2(1 554例),按腰围分为3个等级组:Ⅰ组<85(男)/80(女)cm(1 657例)、Ⅱ组85~〈90(男)/80~〈85(女)cm(973例)、Ⅲ组≥90(男)/85(女)cm(3 107例)。应用中国多省队列研究(CMCS)10年冠心病发病风险预测模型,探究体重指数及腰围与冠心病发病风险的关系。结果 体重指数C组和腰围Ⅲ组高血压、高总胆固醇、低HDL-C和糖尿病比例较大(均P<0.01)。体重指数各等级组的10年冠心病发病风险绝对值随腰围水平的增加而增加(趋势检验P<0.000 1);对于腰围水平低的对象,其体重指数水平越高,冠心病发病风险绝对值越高(趋势检验P=0.000 6)。多因素Logistic分析显示,对于同一体重指数(或腰围)等级的研究对象,其10年冠心病发病风险随腰围(或体重指数)水平的增加而增加(趋势检验P<0.05);体重指数C组且腰围Ⅲ组的冠心病发病风险最大(比值比=4.191,95%置信区间:3.578~4.909)。结论 新疆和西藏地区居民体重指数和腰围是10年冠心病发病风险的独立影响因素,体重指数和腰围同时处于较高水平者或是10年冠心病发病的高危人群。
Objective To investigate the association among body mass index(BMI), waist circumference(WC) and the 10-year coronary atherosclerotic heart disease(CHD) in Xinjiang and Tibet areas of China. Methods Based on stratified multi-stage random sampling method, 7 631 people of 35 years or older were enrolled from Xinjiang and Tibet regions from June 2015 to March 2017; 5 737 cases with complete data were analyzed. BMI and WC were measured; the population was allocated into group A BMI〈24 kg/m^2(2 005 cases), group B BMI 24-〈28 kg/m^2(2 178 cases), group C BMI≥28 kg/m^2(1 554 cases); group Ⅰ WC〈85(male)/80(female)cm(1 657 cases), group Ⅱ WC 85-〈90(male)/80-〈85(female)cm(973 cases), group Ⅲ WC≥90(male)/85(female)cm(3 107 cases). The relation among BMI, WC and CHD risk was analyzed based on the Chinese Multi-provincial Cohort Study(CMCS) 10-year CHD risk prediction model. Results Group C and group Ⅲ had higher percentages of hypertension, high total cholesterol, low high density lipoprotein cholesterol and diabetes compared to the groups with lower BMI or WC (P〈0.01). The absolute 10-year CHD risk increased with WC in groups with same BMI (P〈0.000 1); it increased with BMI in population with low WC(P=0.000 6). Multivariate logistic analysis showed that 10-year CHD risk increased with BMI(or WC) in groups with same WC(or BMI)(P〈0.05); group C+group Ⅲ had the highest 10-year CHD risk(odds ratio=4.191, 95% confidence interval: 3.578-4.909). Conclusion Both BMI and WC are independently associated with the 10-year CHD risk; the population with higher BMI and WC has a higher 10-year CHD risk in Tibet and Xinjiang areas of China.
作者
郑聪毅
王增武
陈祚
张林峰
王馨
董莹
聂静雨
王佳丽
邵澜
田野
Zheng Congyi Wang Zengwu Chen Zuo Zhang Linfeng Wang Xin Dong Ying Nie Jingyu Wang Jiali Shao Lan Tian Ye(Department of Prevention and Community Health, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences, Beijing 102308, China)
出处
《中国医药》
2017年第7期965-970,共6页
China Medicine
基金
国家卫生和计划生育委员会公益性行业科研专项“西藏和新疆地区慢性心肺疾病现状调查研究”(201402002)