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Axonal microRNAs: localization, function and regulatory mechanism during axon development 被引量:4

Axonal microRNAs: localization, function and regulatory mechanism during axon development
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摘要 Subcellular localization and translation of messenger RNAs are essential for the regulation of neuronal development and synaptic function. As post-transcriptional regulators, microRNAs (miRNAs) have been emerging as central players in the development and maturation of the nervous system. Recent discoveries reveal the critical functions of miRNAs in the axon of neurons via multiple pathways of molecular regulation. Here, we introduce methods for isolating axonal miRNAs and review recent findings on the localization and function as well as regulatory mechanism of axonal miRNAs during axon development.
作者 Bin Wang Lan Bao
出处 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2017年第2期82-90,共9页 分子细胞生物学报(英文版)
关键词 axonal miRNA compartmentalized culture axon development RNA-binding protein 神经元轴突 亚细胞定位 发育过程 调控机制 miRNAs 微结构 messenger microRNA
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