摘要
目的:研究胰岛素泵持续皮下注射对妊娠期糖尿病(GDM)患者糖脂代谢及胎盘中炎症反应、氧化应激反应的影响。方法:选择接受胰岛素治疗的GDM患者作为研究对象,随机分为胰岛素多次皮下注射(MSII)组和胰岛素泵连续皮下输注(CSII)组。治疗前后分别测定血清中糖脂代谢以及胎盘中炎症反应、氧化应激反应指标。结果:治疗后2、4周时,两组FBG、1hPBG、2hPBG、Chemerin、Vaspin、Visfatin的含量均显著低于治疗前且CSII组FBG、1hPBG、2hPBG、Chemerin、Vaspin、Visfatin的含量均显著低于MSII组;分娩后,CSII组患者胎盘中TNF-α、IL-6、ROS、AGEs的含量显著低于MSII组。结论:胰岛素泵持续皮下注射能够较胰岛素多次皮下注射更为有效的改善GDM患者的糖脂代谢并抑制胎盘中的炎症反应、氧化应激反应。
Objective：To study the effect of continuous subcutaneous insulin pump infusion on glucolipid metabolism as well as inflammation and oxidative stress in placenta of patients with gestational diabetes mellitus（GDM）.Methods：Patients with GDM who received insulin therapy between March 2013 and May 2016 were selected as the research subjects and randomly divided into multiple subcutaneous insulin injection（MSII）group and continuous subcutaneous insulin pump infusion（CSII）group.Before and after treatment,serum glucolipid metabolism as well as inflammation and oxidative stress inexes in placenta were determined respectively.Results：2weeks and 4weeks after treatment,FBG,1hPBG,2hPBG,Chemerin,Vaspin and Visfatin levels of both groupss of patients were significantly lower than those before treatment and FBG,1hPBG,2hPBG,Chemerin,Vaspin and Visfatin levels of CSII group were significantly lower than those of MSII group;after delivery,TNF-α,IL-6,ROS and AGEs levels in placenta of CSII group were significantly lower than those of MSII group.Conclusion：Continuous subcutaneous insulin infusion can more effectively improve the glucolipid metabolism and inhibit the inflammation and oxidative stress in placenta of patients with GDM than multiple subcutaneous insulin injection.
出处
《海南医学院学报》
CAS
2017年第9期1203-1205,1209,共4页
Journal of Hainan Medical University
基金
四川大学华西附属二医院课题项目(15H0056)~~
