摘要
【目的】综合评价循环辅助性T细胞17与冠心病之间的关系,为冠心病的预防和诊治提供依据。【方法】计算机检索中国知网数据库、中国生物医学数据库、万方数据库、维普数据库、Pubmed、EMBase、Cochrane图书馆,收集国内外公开发表的关于Th17细胞与冠心病关系的病例对照研究,采用ReMan5.3软件进行meta分析。【结果】共纳入8项研究,共713例研究对象。按照Th17细胞抗体标记不同,分为CD4^+IL-17^+亚组和CD4^+INFγ+IL-17^+亚组,分别包含5项、4项研究。Meta分析结果显示,不同抗体标记的Th17细胞,急性心肌梗死组、不稳定性心绞痛组与对照组相比,数量都明显增高,CD4^+IL-17^+组WMD分别为{-3.81[-4.24,-3.39],Z=17.45(P<0.001)}、{-4.28[-5.94,-2.63],Z=5.06(P<0.001)};CD4^+INFγ+IL-17^+组WMD分别为{-1.99[-2.83,-1.16],Z=7.49(P<0.001)}、{-2.62[-3.20,-2.05],Z=8.91(P<0.001)}。稳定性心绞痛组与对照组对比,细胞数量增多无统计学差异,WMD分别为{-1.33[-2.14,-0.51],Z=3.20(P=0.001)}、{-0.61[-1.03,-0.19],Z=2.85(P=0.004)}。急性心肌梗死组与稳定性心绞痛组对比,细胞数量明显增多,WMD分别为{-3.07[-3.44,-2.70],Z=16.23(P<0.001)}、{-1.37[-1.79,-0.94],Z=6.31(P<0.001)}。【结论】Th17细胞在急性冠脉综合征中显著升高,与急性冠脉综合征的发生发展密切相关,可能成为诊断和判断预后的新靶点。
[ Objective ] To systematically evaluate the relationship between circulating T helper 17 （Th 17） cells and coronary heart disease （CHD）, and provide evidence for the CHD prevention and treatment. [ Methods ] Case-control articles published at home and abroad on the relationship between Thl7 cells and CHD were searched from CNKI, China biomedical database, Wanfang database, VIP database, PubMed, EMBase and Cochrane library. Meta-analysis was performed via RoManS.3 software. [ Results] A total of 8 studies and 713 subjects were included. Aceording to different antibodies, Thl7 cells were marked with CD4＋IL-17＋ and CD4＋INF＂/＋IL-17＋ and divided into 2 subgroups （n=5, n=4）. The results of meta-analysis showed that Thl7 eells marked with different antibodies significantly increased in the acute myocardial infarction （AMI） group and unstable angina pectoris （UA） group, compared with the control group. The values of weighted mean difference （WMD） in the CD4＋IL-1T subgroup and the CD4＋INF＂/＋IL-17＋ subgroup were {-3.81[-4.24, -3.39], Z=17.45（P〈0.O01）}, {-4.28[-5.94, - 2.63], Z=5.06 （P〈0.001）}, {-1.99[-2.83,-1.16], Z=7.49（P〈0.001）} and {-2.62 [-3.20, -2.05], Z=8.91（P〈0.001）} respectively. But there was no statistical difference in Thl7 cells between the stable angina pectoris group and the control group. The values of WMD were {-1.33 [-2.14, - 0.51 ], Z=3.20（P=0.001 ）} and {-0.61 [- 1.03, -0.19], Z=2.85 （P=0.004）} respectively. The Th 17 cells in the AMI group were obviously more than those in the stable angina pectoris group. The values of WMD were {23.07 [-3.44, -2.70], Z=16.23（P〈0.001）}, {-1.37 [-1.79, -0.94], Z=6.31（P〈0.001）} respectively. [Conclusion ] Thl7 cells significantly increase in acute coronary syndrome and closely relate to its genesis and development. Therefore, Thl7 cells may turn to a new target for the diagnosis and prognosis judgement.
出处
《武警后勤学院学报（医学版）》
CAS
2017年第2期93-98,共6页
Journal of Logistics University of PAP（Medical Sciences）
基金
国家自然科学基金面上项目(81570335)
