摘要
目的了解体检人群高尿酸血症(HUA)与铁蛋白及血浆致动脉硬化指数(AIP)等指标的关系,为HUA的预防控制提供参考依据。方法选择2005年1月-2015年12月在温州医科大学附属第一医院体检者7 458例,测定血尿酸(SUA)、血清铁蛋白(SF)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、血肌酐(CR)、尿素氮(BUN)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C),计算非高密度脂蛋白胆固醇(non-HDL-C)、血浆致动脉硬化指数(AIP)、动脉硬化指数(ASI),根据诊断标准进行分组,利用统计软件进行相关性分析。结果在男性和女性人群中,高尿酸组SF、ALT、AST、CR、BUN、TG、TC、LDL-C、non-HDL-C、AIP、ASI水平均高于正常尿酸组,高尿酸组HDL-C水平低于正常尿酸组,差异有统计学意义(P<0.01);男性和女性人群中UA水平与SF、ALT、AST、CR、BUN、TG、TC、LDL-C、non-HDL-C、AIP和ASI均呈正相关(P<0.01),与HDL-C呈负相关(P<0.01);ROC曲线结果显示,SF、ALT、AST、CR、TG及AIP这6种指标进行联合检测时的AUC(0.820)均大于12种指标单独进行检测时的AUC。结论体检人群高尿酸血症存在血脂、肾功能、肝功能相关指标紊乱,SF、ALT、AST、CR、TG及AIP联合检测对高尿酸血症的鉴别诊断具有一定的临床应用价值。
Objective To analyze the correlation of hyperuricemia and ferritin and atherogenic index of plasma（AlP） , so as to provide reference for the prevention and control of hyperuricemia. Methods Blood samples were collected from 7 458 physical examinees from the First Affiliated Hospital Of Wenzhou Medical University during January 2005 - December 2015 for testing the concentrations of SUA, SF, ALT, AST, CR, BUN, TG, TC, HDL - C, LDL - C and calculated non - HDL - C, AIP, ASI, and grouped based on the diagnostic criteria and used statistical software for correlation analysis. Results Compared with hyperuricemia group, the cases with normal uric acid group had higher average level of SF, ALT, AST, CR, BUN, TG, TC, LDL - C, non - HDL - C, AlP, ASI and had lower level of HDL - C between in male and female population（ P 〈0.01 ）. UA was positively correlated with SF, ALT, AST, CR, TG, non - HDL - C, AIP, ASI（P 〈0.01 ） and was negatively with HDL - C in male and female population（ P 〈 0.01 ）. The results of ROE showed that the AUC （0. 820） of joint detection of the six in- dexes such as SF, ALT, AST, CR, TG, AIP was higher than the AUC of the separate detection of 12 indexes. Conclu- sion Hyperuricemia is concerned with the disordered indexes of blood lipid, renal function, liver function from the physical ex- amination population. The joint detection of SF, ALT, AST, CR, TG, AlP has certain clinical application value for differential diagnosis of hyperurieemia.
出处
《中国卫生检验杂志》
CAS
2017年第11期1532-1535,1538,共5页
Chinese Journal of Health Laboratory Technology
基金
国家自然青年基金(81401736)
浙江省医药卫生项目(2014KYA133)
温州市科技局课题(Y20150097)
