摘要
恶性肿瘤骨转移发病率较高,且严重影响患者的生存质量,故明确其发生机制对恶性肿瘤的预防和治疗都有重要意义。目前已证实肿瘤微环境在原发肿瘤迁移过程中起重要作用,而基质蛋白是骨髓微环境的重要组成成分。最新的研究发现基质蛋白可通过促进肿瘤细胞的增殖、侵袭和转移,进而参与骨转移过程。本文就基质蛋白在恶性肿瘤骨转移过程中的调控作用加以综述。
The incidence of bone metastases in malignant tumors is high, and seriously affected the life quality of patients. It is clear that the mechanism of the prevention and treatment of malignant tumors are of great significance. It has been confirmed that tumor microenvironment plays an important role in the migration of prima-ry tumors, and the matrix protein is an important component of bone marrow microenvironment. In recent years, the latest study has been found that matrix proteins can be involved in the process of bone metastasis by promoting tumor cell proliferation,invasion and metastasis. In this paper,the role of matrix proteins in the process of bone metastasis of malignant tumors was reviewed.
出处
《实用肿瘤学杂志》
CAS
2017年第3期285-288,共4页
Practical Oncology Journal
关键词
基质蛋白
骨髓基质
骨转移
Matrix proteins
Bone marrow matrix
Bone metastases
