摘要
目的探讨妇科肿瘤与乳腺癌伴绝经患者骨质疏松的临床治疗方法及效果。方法选取2014年8月至2015年9月收治的妇科肿瘤／乳腺癌伴绝经患者90例，其中妇科肿瘤55例，乳腺癌35例。按患者入院先后顺序进行编号，编号奇数者归为观察组，编号偶数者归为对照组，每组45例。对照组行绝经后骨质疏松常规治疗，观察组在此基础上静脉注射唑来膦酸同时口服来曲唑，对比两组骨密度（BMD）、骨钙素（BGP）及骨矿含量（BMC），评估关节疼痛程度，观察不良反应发生情况。结果观察组患者治疗后BMD、BGP、BMC均明显高于治疗前，且明显高于对照组治疗后，关节疼痛视觉模拟评分（VAS）明显降低，较对照组改善更加显著，差异均有统计学意义（P〈0．05）；两组患者复查血、尿常规，肝、肾功能及心电图均未见明显异常，不良反应发生率比较差异无统计学意义（P〉0．05）。结论对妇科肿瘤与乳腺癌伴绝经患者进行放疗及常规骨质疏松治疗的同时静脉注射唑来膦酸口服来曲唑可提升疗效，安全性高，值得临床借鉴。
Objective To study the gynecological tumors and breast cancer associated with the clinical treatment of patients with postmenopausal osteoporosis and effects. Methods August 2014 to September 2015 of 55 cases of gynecological tumors and 35 ca- ses of breast cancer patients, randomly divided into two groups, the control line in postmenopausal osteoporosis routine therapy, ob- servation group on the basis of intravenous azole [etrozole,phosphonic acid and oral contrast two groups of bone mineral density （BMD） ,osteocalcin（BGP） and bone mineral content（BMC） and assess the degree of joint pain, observe any adverse reactions occur. Results Observation group of BMD,BGP and BMC value was significantly increased the,and significantly higher than that of con- trol group,joint pain VAS scores significantly lower, than the control group improved more significantly, compared the statistical difference between groups（P〈0. 05） ,two groups of blood in the urine routine,liver and kidney function,and review of the electro- cardiogram（ecg） were not seen obvious abnormity, there is no statistical difference between the incidence of adverse reactions groups（P〈0.05）. Conclusion The gynecologic tumor with postmenopausal patients with breast cancer radiotherapy and conven- tional osteoporosis therapy and intravenous azole to phosphonic acid letrozole can improve curative effect of oral, high safety, is wor- thy of reference for clinical.
出处
《重庆医学》
CAS
北大核心
2017年第A01期203-205,共3页
Chongqing medicine
关键词
妇科肿瘤
乳腺癌
绝经
骨质疏松
临床疗效
gynecologic tumors, Breast cancer
Menopause
Osteoporosis
Clinical curative effect
