摘要手足口病(Hand,foot and mouth disease,HFMD)是儿童常见的急性传染病,以发热和手、足、口腔等部位的皮疹或疱疹为主要表现,少数患儿可并发无菌性脑膜炎、脑干脑炎、脑脊髓炎等严重神经系统疾病,预后差,病死率高。多种人类肠道病毒可引起HFMD,以肠道病毒71型(EV71)和柯萨奇病毒最为常见,
9Brown BA, Oberste MS, Alexander JP Jr, et al. Molecu- lar epidemiology and evolution of enterovirus 71 strains isolated from 1970 to 1998 [J]. J Virol, 1999, 73: 9969-9975. 被引量:1
10Yoke-Fun C, AbuBakar S. Phylogenetic evidence for inter- typic recombination in the emergence of human enterovirus 71 subgenotypes[J]. BMC Microbiol, 2006, 6: 74-84. 被引量:1