摘要
磺脲类(SUs)降糖药与心血管风险的关系备受关注,既往部分研究发现,SUs增加T2DM患者的心血管风险,而另一部分研究则发现SUs不增加心血管风险。临床研究发现,不同SUs的心血管风险可能存在差异,与其他SUs相比,格列齐特和格列美脲可能具有较低的心血管风险。本文从循证证据方面对SUs的心血管安全性及近期相关研究进展进行阐述。
The relationship between Sulfonylureas(SUs) and cardiovascular (CV) risks has attracted great attention. Previous studies have illustrated that some SUs increase CV risk in type 2 diabetes (T2DM) patients, while others do not. Clinical studies have found that the CV risks of different SUs may be different. Compared with other SUs, glimepiride and gliclazide may have lower CV risks. Here we reviewed evidence-based CV safety of SUs and the recent research progress.
出处
《中国糖尿病杂志》
CAS
CSCD
北大核心
2017年第6期573-576,共4页
Chinese Journal of Diabetes
关键词
糖尿病
2型
磺脲类
心血管风险
Diabetes mellitus, type 2
Sulfonylureas
Cardiovascular risk