摘要
目的:观察丹鳖胶囊对子宫内膜异位症(EMs)大鼠血清前列腺素E_2(PGE_2)和前列腺素F_2α(PGF_2α)浓度的影响,探讨丹鳖胶囊对子宫内膜异位症治疗作用的机制。方法:建立EMs大鼠模型并将造模成功的大鼠随机分为丹鳖胶囊高剂量组、丹鳖胶囊低剂量组、桂枝茯苓胶囊对照组、模型组、假手术组,每组10只。分别给予丹鳖胶囊高、低剂量药液及桂枝茯苓胶囊混悬液、0.9%氯化钠注射液灌胃12d。观察治疗后血PGE_2及PGF_2α浓度的变化。结果:治疗后丹鳖胶囊高、低剂量组和桂枝茯苓胶囊对照组PGE_2及PGF_2α浓度低于模型组(P<0.05);丹鳖胶囊高剂量组PGE_2及PGF_2α浓度低于丹鳖胶囊低剂量组及桂枝茯苓胶囊对照组(P<0.05)。结论:丹鳖胶囊能降低EMs大鼠血清PGE_2及PGF_2α的浓度,这可能是其治疗子宫内膜异位的作用机制之一。
Objective：To investigate the effect of Danbie capsules on the serum levels ofprostaglandinE2 （PGE2 ） and prostaglandin F2α（PGF2α）in rats with endometriosis and the mechanism of action of Danbie capsules in the treatment of endometriosis （EMs）. Methods ： A rat model of EMS was established and the rats were randomly divided into high - and low- dose Danbie capsule groups, Guizhi Fuling capsule control group, model group, and sham - operation group,with 10 rats in each group. The rats in these groups were treated withhigh - or low- dose Danbie capsule solution, Guizhi Fuling capsule suspension, or 0. 9% sodium chloride injection by garage for 12 days. The changes in serum levels of PGE2and PGF2ot after treatment were observed. Results：After treatment, the high - and low -dose Danbie capsule groups and the Guizhi Fuling capsule control group had significantly lower levels of PGE2 and PGF2α than the model group （P 〈 O. 05 ）. The high - dose Danbie capsule group had significantly lower levels of PGE2and PGF2α than the tow -dose Danbie capsule group and the Guizhi Fuling capsule control group （P 〈0.05）. Conclusion：Danbie capsules can reduce the serum levels of PGE2and PGF2α in EMS rats,which may be one of its mechanisms of action in the treatment of EMs.
出处
《湖南中医杂志》
2017年第5期167-169,共3页
Hunan Journal of Traditional Chinese Medicine
