摘要
目的观察糖肾1号方结合西医常规疗法治疗气阴两虚型Ⅲ期糖尿病肾病的临床疗效。方法将60例气阴两虚型Ⅲ期糖尿病肾病患者随机分为治疗组和对照组,每组30例。两组均予西医常规疗法,治疗组在此基础上加服糖肾1号方。两组疗程均为3个月,观察临床疗效,比较中医证候积分及尿白蛋白排泄率(UAE)、血肌酐(Scr)、糖化血红蛋白(Hb A1c)、纤维蛋白原降解产物(FDP)、总胆固醇(TC)、三酰甘油(TG)等生化指标的变化情况。结果 (1)治疗组、对照组临床总有效率分别为86.67%、60.00%;组间临床疗效比较,治疗组明显优于对照组(P<0.05)。(2)组间治疗前后中医证候积分差值比较,差异有统计学意义,治疗组中医证候积分改善程度比对照组更加显著(P<0.05)。(3)组间治疗后比较,UAE、TG及FDP水平差异有统计学意义(P<0.05)。结论糖肾1号方可改善气阴两虚型糖尿病肾病Ⅲ期患者的临床症状、降低尿微量白蛋白,其机制可能与调节脂质代谢、改善肾脏血流动力学有关。
Objective To observe the clinical efficacy of No. 1 Tangshen Decoction combined with routine therapy of western medicine in treating diabetic nephropathy of stage Ⅲ with syndrome of qi-yin deficiency. Methods Sixty patients of stage Ⅲ diabetic nephropathy with syndrome of qi-yin deficiency were randomly divided into the treatment group and control group,30 cases in each group. Both groups were treated with routine therapy of western medicine, and the treatment group was treated with No. 1 Tangsben Decoction additionally, with a course of 3 months. The clinical efficacy was observed, and the changes of TCM syndrome score, urinary albumin excretion rate （UAE） , serum creatinine （Scr） , glycosylated hemoglobin （HbAlc）, fibrinogen degradation products （FDP）, total cholesterol （TC） and triacylglycerol（TG） were compared. Results （1）Tbe clinical total effective rate was 86.67% in the treatment group and 60.00% in the control group. The clinical efficacy of the treatment group was significantly better than that of the control group（ P 〈 0.05 ）. （~）For the comparison of the difference of TCM syndrome score between treatment before and after,there was statistically significant difference between the two groups. The improvement on TCM syndrome score in the treatment group was more significant than that in the control group （ P 〈 0.05 ）. （~）After treatment, there were statistically significant differences on the levels of UAE, TG and FDP between the two groups （ P 〈 0.05 ）. Conclusion No. 1 Tangshen Decoction can improve the clinical symptoms of patients of stage Ⅲ diabetic nephropathy with syndrome of qi-yin deficiency, and decrease the urinary microalbumin. Its mechanism may be related to regulating lipid metabolism and improving renal hemodynamics.
出处
《上海中医药杂志》
2017年第6期56-59,共4页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然基金面上项目(81373615)
关键词
糖尿病肾病
糖肾1号方
气阴两虚
瘀血阻络
糖脂代谢紊乱
diabetic nephropathy
No. 1 Tangshen Decoction
qi-yiu deficiency
collaterals obstruction by blood stasis
glucose and lipid metabolism disorder
