摘要
目的:探讨受体相互作用蛋白1在结肠癌中的表达及其与临床病理特征的关系。方法:使用免疫组织化学检测97例结肠癌组织及癌旁组织中受体相互作用蛋白1的表达情况,结合临床病理资料进行统计学分析。结果:97例结肠癌患者中,癌组织中受体相互作用蛋白1阳性表达的有41例(42.3%),癌旁组织中阳性表达的有78例(80.4%),差异有统计学意义(P<0.05)。结肠癌组织中受体相互作用蛋白1的表达与年龄、性别无关,与患者临床分期、病理分级、淋巴结转移相关。结论:结肠癌中受体相互作用蛋白1表达降低可能是判断结肠癌患者预后一个潜在参考指标。
Objective：To study the expression and significance of receptor interacting protein 1（RIP1）in colon cancer. Method：The expression of RIP1 in colon cancer tissues and tissue adjacent to carcinoma, which were col- lected from 97 cases,is examed with immunohistochemical assay. The results then were applied to perform statisti- cal analysis,combining with clinical pathological data. Result：Among these patients,RIP1 is positively expressed in 41 cases, accounted for 42.3 % ,and 78 cases in the adjacent tissues,accounted for 80.4%. The difference was sta- tistically significant （P〈0.05）. RIP1 expression in cancerous tissue has nothing to do with patient age and gen- der. However, it is associated with clinical stage, pathologic stage, lymph node metastasis. Conclusion：The down- regulated expression of RIP1 in colon cancer may he a potential reference designator to judge the prognosis of pa- tients with colon cancer.
出处
《临床急诊杂志》
CAS
2017年第5期345-347,共3页
Journal of Clinical Emergency
基金
国家自然科学基金项目(No:81370562)
国家自然科学基金青年项目(No:81300356
81500488)
关键词
受体相互作用蛋白1
结肠癌
免疫组织化学
receptor interacting protein 1（RIP1）
colon cancer
immunohistochemistry
