摘要
目的 了解潮汕地区呼吸道感染患儿腺病毒流行情况及临床特征.方法 收集2012年7月至2016年6月因呼吸道感染入住汕头大学医学院第二附属医院儿科患儿的咽拭子标本2 668份,应用多重聚合酶链反应（PCR）技术,对咽拭子标本行腺病毒、呼吸道合胞病毒、人鼻病毒、WU多瘤病毒、人博卡病毒、流感病毒A、B型、副流感病毒1、3型、人类偏肺病毒共10种（型）病毒检测,并对腺病毒阳性病例进行临床资料分析.结果 2 668份咽拭子标本中,病毒阳性1 388份（52.02%）,其中腺病毒95例（3.53%）;腺病毒感染呈全年散发,年龄主要集中发生在6岁以下,尤其是3岁以下;主要临床症状表现为发热、咳嗽、喘息、气促,其中混合感染组中,随着合并感染病毒数增加,咳嗽、喘息症状越明显,95例中仅4例（4.21%）患儿符合重症肺炎诊断.结论 腺病毒2012年7月至2016年6月腺病毒在潮汕地区没有发生规模以上的流行和暴发;腺病毒与其他病毒混合感染普遍存在;呼吸道腺病毒感染的临床表现和实验室检查及影像学检查均无特异性特征,但随着合并感染病毒种类数目的增加,咳嗽、喘息、气促发生率更高;近4年来潮汕地区腺病毒呼吸道感染临床症状普遍较轻,重症肺炎发生率低.
Objective To investigate the prevalence of Adenovirus（ADV） in respiratory infections in cilldren of chaoshan area and study the clinical symptoms associated with it.Methods 2 668 nasopharyngeal aspirates specimens （NPA） were collected from children with respiratory tract infection from July 2012 to June 2016 in the Second Affiliated Hospital of Shantou University Medical College.Multiplex polymerase chain reaction （PCR） was applied to detect 10 kinds of viruses including adenovirus （ADV）,respiratory syncytial virus （RSV）,Human Rhinoviruses（HRV）,WU Polyomavirus（WUPyV）,human Boca virus （HBoV）,influenza virus A,B type （InfA、InfB）,parainfluenza virus type 1,3,（PIV-1、PIV-3）,human metapneumovirus （HMPV）.The clinical characteristic of these ADV-positive cases were analyzed.Results There were 1 388 samples （52.02%） of the 2 668 NPA specimens were positive for viruses,which included 95（3.53%） cases positive for ADV.ADV infection could occur in a whole year and occurred in children at age of 0-6 years,especially at age of 0-3 years.The clinical symptoms of ADV infection included fever,cough,wheeze and polypnea.The co-infection group,with the increase of the number of the virus,the more obvious symptoms of cough and wheezing.Only 4 cases （4/95,4.21%） diagnosed as severe pneumonia.Conclusions ADV infection is not in the pandemic stage in chaoshan area from July 2012 to June 2016.ADV co-infected with other virus are common.The clinical manifestation,laboratory examination and imaging examination in children with ADV infection show no specific features.The co-infection groups,with the increase of the number of the virus,the more obvious symptoms of cough and wheezing.The clinical symptoms are generally mild for nearly 4 years of ADV respiratory infection in chaoshan area which has a low incidence of severe pneumonia.
出处
《国际呼吸杂志》
2017年第10期745-751,共7页
International Journal of Respiration
基金
广东省医学科学技术研究基金（A2015431）
广东省高水平大学重点学科建设项目-“感染性疾病研究与防治”（2050205）
关键词
腺病毒
呼吸道感染
临床特征
重症
Adenovirus
Respiratory infections
Clinical symptoms
Severe
