摘要
目的比较不同剂量复方米非司酮联合米索前列醇终止8~16周妊娠的效果。方法将妊娠8~16周自愿要求终止妊娠的健康孕妇64例随机分为A组与B组各32例,A组每12小时口服复方米非司酮30mg,共4次,第3天口服米索前列醇片600μg;B组每24小时口服复方米非司酮30mg,共2次,第3天口服米索前列醇片600μg。口服米索前列醇后4小时无组织物排出,则重复给予米索前列醇200μg口服,每天不超过5次,48小时无妊娠物排出定义为药流失败。结果 A组完全流产率87.5%;B组完全流产率81.3%;差异无显著性(P=0.732)。A组和B组服用米索前列醇至胎盘娩出的中位时间分别为3.0小时和4.8小时,差异有显著性(P=0.003)。A组和B组的米索前列醇加药例数分别为7例和16例,差异有显著性(P=0.036);需加药2次及以上者分别为5例和10例;两组米索前列醇的用药总量分别为21.0mg和26.6mg,差异有显著性(P=0.018)。两组均无严重不良反应及过敏反应发生,无子宫破裂、输血病例。结论复方米非司酮联合米索前列醇用于终止8~16周妊娠流产成功率高。增加复方米非司酮剂量可以缩短流产时间、减少米索前列醇用量。
Objective To compare the effect of two does compound mifepristone in combination with misoprostol for medical abortion to 8 - 16 weeks of gestation. Method 64 consenting women with maternal or fetal indications for pregnancy termination were randomly assigned to receive either oral compound mifepristone 30mg every 12 hours 4× （group A,n= 32）or 30mg every 24 hours 2× （group B, n = 32）in combination with oral misoprostol 600μg at the third day. Both groups received misoprostol 200μg every 4 hours until delivery for no more than 5 times a day. Suc- cess was defined as induced abortion within 48 hours at the first administration of misoprostol. Result Demographic characteristics were similar between study groups. The success rates of group A and group B were 87. 5% and 81.3% respectively without significant difference（ P = 0. 732）. Median induction-to-delivery interval since first ad- ministration of misoprostol was significantly shorter in group A （ 3.0 hours ） than in group B （ 4. 8 hours ） （ P = 0. 003）. The total dose of adverse reaction was less in group A than in group B（P= 0.018）. There was no serious adverse reaction, uterine rupture or blood transfusionin both groups. Conclusion Compound mifepristonc combined with misoprostol for medical abortion to 8 - 16 weeks of gestation is effective. High-dose compound mifepristone is associated with significantly shorter induction-to-delivery intervals and less dose of misoprostol.
出处
《中国临床医生杂志》
2017年第6期36-38,共3页
Chinese Journal For Clinicians
基金
全军优生优育与计划生育重点课题(16GS003)
关键词
流产
复方米非司酮
米索前列醇
8~16周妊娠
Medical abortion
Compound mifepristone
Misoprostol
8 - 16 weeks of gestation
