摘要
阿尔茨海默病(AD)是最常见的中枢神经系统退行性疾病,主要临床表现为进行性认知功能障碍和行为损伤。近年研究显示,微小RNAs(miRNAs)在以AD为代表的中枢神经系统疾病病变过程中发挥了重要调控作用。现综述miRNAs在AD发病的关键病理特征——Aβ的沉积和Tau磷酸化中的调节作用,以期对AD发病机制的认识和诊治新策略的开发提供帮助。
Alzheimer’s disease（AD）, with main clinical features of progressive impairment in cognitive and behavioral functions, is the most common degenerative disease of the central nervous system. Recent literatures documented that micro RNAs（miRNAs） played important roles in the pathological progression of AD, the representative for central nervous system diseases. This article reviews the regulatory role of mi RNAs in both Aβ deposition and Tau phosphorylation, two key pathological characters in the pathology of AD, which might be helpful for the understanding of pathogenesis and development of new strategies of diagnosis and treatment.
出处
《生命科学》
CSCD
2017年第5期507-513,共7页
Chinese Bulletin of Life Sciences
基金
国家自然科学基金项目(31370918)
贵州省高层次创新型人才项目(黔科合人才(2016)4031号)
遵义医学院优秀青年人才计划(15ZY-001)
遵义市科技局遵义医学院2016年科学技术联合资金项目(遵市科合社字(2016)38号)
