摘要
目的:观察高通量血液透析(high-flux hemodialysis,HFD)对维持性血液透析(maintenancehemodialysis,MHD)患者同型半胱氨酸(homocysteine,Hcy)水平及主要心血管事件的影响。方法:选取符合入选条件的患者,随机分为高通量血液透析(HFD)组及低通量血液透析(HD)组,观察12月,主要观察血清同型半胱氨酸(Hcy)、记录主要心血管事件及各临床指标的变化情况并进行相关分析。结果:两组各入选30例,患者年龄、性别、原发病、透析龄等相匹配,HFD组与HD组透前Hcy基线值水平比较(21.02±11.79 vs.19.86±6.97 mmol/L)差异无统计学意义(P=0.162),观察12月后HFD与HD组透前血Hcy水平差异有统计学意义(20.29±11.45 mmol/L vs.24.57±13.23 mmol/L),(P=0.045);观察期间HFD组主要心血管事件发生率较HD组(10.0%vs.33.3%)显著降低(P=0.034),HFD组无死亡,HD死亡1例,全因死亡率差异无统计学意义(P>0.05)。结论:长期HFD治疗显著降低MHD患者透前Hcy水平及主要心血管事件的发生率。
Objective To observe the influence of highflux hemodialysis （HFD） on homocysteine （Hcy） level and major cardiovascular events of maintenance hemodialysis （MHD） patients. Methods Patients eligible for inclusion were randomly divided into HFD group and low flux hemodialysis （HD） group with 30 cases in each group. Patient＇s serum homocysteine （Hcy） , major cardiovascular events and various clinical indicators were observed for 12 months then the data were analyzed. Results Hcy baseline levels in 2 groups（21.02± 11.79 mmol/L vs. 19.86 ± 6.97 mmol/L） indicated no significant difference （P = 0.162） before hemodialysis but Hcy levels had significant difference （20.29 ± 11.45 mmol/L vs. 24.57 ±13.23 mmol/L）, （P = 0.045 ）after 12-month observation. There was lower incidence of major cardiovascular events in HFD when compared to that in HD group （ 10.0% vs. 33.3% ） which showed significantly statistical difference （P=0.034） , and there was no mortality in HFD group but 1 case of death in HD group. All-cause mortality in 2 groups showed no significant difference （P 〉 0.05 ）. Conclusion Long-term HFD treatment significantly reduces Hey levels and the incidence of major cardiovascular events of MHD patients
出处
《实用医学杂志》
CAS
北大核心
2017年第10期1544-1547,共4页
The Journal of Practical Medicine
基金
佛山市卫生和计生局医学科研课题(编号:2015127)
2013年佛山市创新型城市建设科技项目-佛山市科技创新平台(编号:2013AG10008)
