摘要
采用流变仪测定聚维酮K30的流变曲线、屈服值和触变性,考察了测定温度对样品流变学性质的影响。通过试验确定用流变仪测定聚维酮K30黏度的温度为(25±0.1)℃、剪切应力为0.2 Pa,测得样品溶液和溶剂水的动力黏度,通过计算可得样品的相对黏度和K值。本法操作简捷、准确、适用性广、重现性好。相比传统的乌氏毛细管黏度计法,本法中流变仪温控系统可快速精准地控制样品达到预定温度,精度可达0.01℃;除配制、添加样品外,其余操作均由仪器自动完成,减少了手工操作和人为判断引起的实验误差。
The rheological curve, yield value and thixotropy of povidone K30 were measured, and the effect of temperature on the rheological properties of the samples were investigated by the rheometer. It was determined to be （25±0.1） ℃ for the measurement of povidone K30 viscosity by the rheometer, and the corresponding shear stress was 0.2 Pa. The dynamic viscosities of the sample solution and water were measured. The relative viscosity and K value of the samples were calculated. This method was simple, rapid and accurate, with wide applicability and good reproducibility.Compared with the traditional Ubbelohde capillary viscometer method, the temperature control system of the rheometerin this method can quickly and accurately control the sample to the predetermined temperature, with the accuracy of 0.01 ℃. In addition, all procedures can be automatically completed except the preparation and addition of the samples. It contributes to reducing the experimental error caused by manual operation and artificial judgment.
作者
陈燕平
张欣耘
史晓晔
潘颖
陈桂良
CHEN Yanping ZHANG Xinyun SHI Xiaoye PAN Ying CHEN Guiliang(Shanghai Institute for Food and Drug Control, Shanghai 201203 Shanghai Center for Drug Evaluation and Inspection, Shanghai 201203)
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2017年第6期900-903,共4页
Chinese Journal of Pharmaceuticals
基金
国家药典委员会立项课题(1678)
关键词
聚维酮K30
K值
流变仪
药用辅料
povidone K30 K-value rheometer pharmaceutic adjuvant
