摘要
含磷有机化合物在药物化学、材料化学、有机合成化学等领域具有广泛应用,如何高效构建碳-磷键成为有机合成化学领域的研究热点。本文介绍了主要的碳-磷键的构建方法,包括传统的合成方法、常规偶联反应、碳-氢键与磷-氢键直接氧化去氢偶联、磷自由基对不饱和键的多米诺反应及不对称碳-磷键偶联反应等,概述每类方法的优缺点,指出该领域研究目前面临的挑战及发展方向。
Organophosphorus compounds are widely used in pharmacy chemistry, material science, and organic synthesis. So how to construct C-P bonds become a focus in the field of organic synthesis chemistry. In this paper, recent progress in the construction of C-P bonds including traditional synthetic methods, conventional C-P coupling reactions, direct oxidative dehydrogenation coupling, the domino reactions between phosphorus radicals with unsaturated bonds, asymmetric C-P cross-coupling were reviewed. Their advantages and disadvantages, challenges, development directions were also discussed.
作者
王方元
姚克平
彭安顺
王程宇
Wang Fangyuan Yao Keping Peng Anshun Wang Chengyu(School of Chemistry and Chemical Engineering, Linyi University, Linyi 27600)
出处
《化学通报》
CSCD
北大核心
2017年第6期524-532,543,共10页
Chemistry
基金
临沂大学大学生创新创业训练计划项目(201510452122)
临沂大学博士启动基金项目(LYDX2016BS018)资助
关键词
有机磷化学
碳-磷键
偶联反应
磷自由基
Organophosphorus, C-P bonds, Coupling reactions, Phosphorus radicals
