摘要
目的探讨尼卡地平对老年年患者髋关节置换术后认知功能障碍的影响。方法选择2015年10月—2016年10月择期腰硬联合麻醉下行单侧髋关节置换手术的老年患者180例,随机分为尼卡地平组和非尼卡地平组(未用尼卡地平),尼卡地平组术中适时适量静脉泵入尼卡地平0.13~1.00μg·kg^(-1)·min^(-1),非尼卡地平组未使用尼卡地平。观察并记录术前、手术开始30 min后、手术结束时的MAP。应用简易精神状态量表记录患者术前1d、术后1、3、5 d MMSE评分,并记录发生的POCD例数。结果与非尼卡地平组比较,尼卡地平组手术开始30 min后、手术结束时的MAP明显降低(P<0.05)。与非尼卡地平组比较,术后1 d尼卡地平组MMSE评分明显升高(P<0.01)。尼卡地平组发生POCD 8例(8.89%),明显低于非尼卡地平组19例(21.11%)(P<0.05)。结论尼卡地平能维持腰硬联合麻醉行单侧髋关节置换手术患者术中血流动力学稳定,且对术后认知功能障碍有一定的预防作用。
Objective To discuss nicardipin＇s influence on post operation cognitive dysfunction （POCD） in senior patient after hip joint replacement operation. Methods 180 senior patient, who received selective unilateral hip joint re-placement operation between October 2015 and October 2016 under the condition of combined spinal - epidural anesthesia （CSEA） were randomly divided into Group A （with nicardipine） and Group B （without nicardipine） . Nicardipine was only appropriately pumped into vein in time in Group A. MAP was observed and recorded 30 minutes after starting the operation and at the end of the operation. Mini - mental state examination （ MMSE） was applied to score the patient one day before, one day, three days and five days after operation, and the number of POCD was recorded. Results Compared with Group B, Group A was obviously lower in MAP level （P 〈0.05） after 30 minutes. MMSE score of Group A was obviously higher （P 〈 0.01） one day after operation. The number of POCD in Group A was 8 （8. 89% ） significantly lower than than that of Group B （19, 21. 11%）. Conclusion Nicardipine could maintain hemodynamic stability of senior patients receiving selec-tive unilateral hip joint replacement operation under the CSEA and prevent POCD to a certain extent.
出处
《现代医院》
2017年第5期749-751,共3页
Modern Hospitals
关键词
尼卡地平
腰硬联合麻醉
老年患者
髋关节置换术
术后认知功能障碍
Nicardipine
Combined Spinal - epidural Anesthesia
Senior Patient
Hip Joint Replacement Opera-tion
Post Operation Cognitive Dysfunction
