摘要
目的探索膜突蛋白在脑胶质瘤的表达,与临床特征之间的关系及其在临床预后判断的作用。方法收集癌症基因图谱(TCGA)数据库中514例脑胶质瘤病人的临床资料和m RNA芯片数据,分析膜突蛋白表达情况。Kaplan-Meier生存曲线分析膜突蛋白表达与脑胶质瘤病人无疾病生存期以及总体生存期的关系。进一步通过多因素方差分析,研究膜突蛋白表达与病人年龄、性别以及胶质瘤病理级别等之间的关系。结果随着脑胶质瘤病理级别升高,膜突蛋白表达升高(P<0.001)。膜突蛋白表达显著影响胶质瘤病人总体生存期和无疾病生存期,膜突蛋白表达越高,病人总体生存期以及无疾病生存期越短(P<0.001)。结论膜突蛋白可作为潜在肿瘤诊断标志物以及个体化治疗靶点。
Objective To explore the expression of membrane structure extending spike protein （Moesin） in glioma and its relationship with clinical features and its role in clinical prognosis. Methods The clinical data and mRNA microarray data of 514 patients with gliomas obtained from the Cancer Gene Map （TCGA） database were collected and analyzed for expression of Moesin. The Kaplan-Meier survival curve was used to analyze the relationship between the expression of Moesin and survival of patients with glioma. The relationship between Moesin and age, sex and pathologic grade of glioma was further analyzed by multivariate analysis of variance. Results With the pathological grade of glioma increased, Moesin expression increased （P 〈 0.001）. The expression of Moesin was significantly correlated with the overall survival and disease-flee survival of patients with glioma. Patients with higher Moesin expression had shorter overall survival and disease-fi＇ee survival （P 〈 0.001）. Conclusion Moesin may serve as a potential tumor diagnostic markers and an individual therapeutic target.
作者
张哲
杨剑
蒋富强
卢伟
Zhang Zhe Yang Jian Jiang Fuqiang Lu Wei(Department of Interventional Medicine, Navy General Hospital, Beijing 100048, China)
出处
《中国微侵袭神经外科杂志》
CAS
2017年第5期201-204,共4页
Chinese Journal of Minimally Invasive Neurosurgery
关键词
神经胶质瘤
膜突蛋白
治疗靶点
总体生存期
无疾病生存期
gliomas
membrane structure extending spike protein
therapeutic target
overal survival
disease-free survival
