摘要
目的分析肾移植患者颈总动脉形态学参数随年龄变化的斜率,探讨其衰老进程。方法 31例肾移植患者(kidney transplant recipient,KTR),31例维持性血透的终末期肾病(end-stage renal disease,ESRD)患者,84例年龄、性别匹配的对照接受颈动脉超声检查。测量右颈总动脉内-中膜厚度(carotid intima-media thickness,CIMT)和右颈总动脉管径(common carotid artery diameter,CCAD)。CIMT和CCAD随年龄变化的斜率采用线性回归分析。结果 ESRD组患者与KTR组和对照组比较,CIMT增厚,CCAD增宽(P<0.05)。KTR组和对照组之间CIMT和CCAD差异无统计学意义(P>0.05)。CIMT与年龄呈正相关(P<0.05)。CIMT随年龄变化的斜率(回归系数b):对照组大于KTR组和ESRD组(Z=1.417,P=0.006;Z=2.223,P<0.001),KTR组和ESRD组之间的差异无统计学意义(Z=1.038,P=0.723)。CCAD与年龄呈正相关(P<0.05)。CCAD随年龄变化的斜率:ESRD组小于对照组(Z=1.677,P=0.002)。结论肾移植患者颈总动脉形态学部分改善,血管衰老逐步恢复自然进程。
Objective To study the change rules with age in morphologic properties of common carotid artery, and to discuss its aging process after kidney transplantation. Methods Thirty-one patients with end-stage renal disease （ESRD） supported by hemodialysis, 31 kidney transplant recipients （KTR） and 84 control subjects were offered an ultrasound of carotid artery. The carotid intima-media thickness （CIMT） and common carotid artery diameter （CCAD） of right carotid arteries were measured by ultrasonic frequency tracking. The tends for slope of CIMT and CCAD with age were analyzed by linear regression analysis. Results Compared with KTR group and control group,ESRD group had significantly thicker CIMT and wider CCAD, but there was no significant difference between KTR group and control group. The linear regression showed the development of CIMT were positively associated with age （P〈0.05）. Compared with KTR group and ESRD group respectively,the slope ofCIMT with age （unstandardized coefficients b） in control group was greater （Z= 1. 417,P = 0. 006;Z = 2. 223,P〈0. 001）. There was no significant difference between KTR group and ESRD group （Z = 1. 038,P = 0. 723）. The development of CCAD were also positively associated with age （P〈0.05）. Compared with control group, the slope of CCAD with age in ESRD group was less （Z = 1. 677, P = 0. 002）. Conclusions After successful kidney transplantation, some morphologic properties of carotid artery are improved and resume the normal aging process.
出处
《复旦学报（医学版）》
CAS
CSCD
北大核心
2017年第3期261-266,共6页
Fudan University Journal of Medical Sciences
基金
上海市科学技术委员会医学引导类科技项目(15411969100
16411969300)
上海市卫生和计划生育委员会基金(201440290
201640043)
上海交通大学医工交叉研究基金(YG2015MS28)~~
关键词
肾移植
终末期肾病
颈总动脉
形态学
衰老
超声
kidney transplantation
end-stage renal disease
common carotid artery
morphology
aging
ultrasound
