摘要
目的探讨IVF-ET治疗中GnRH激动剂方案促排卵的适宜获卵数。方法回顾性分析2014年1月至2015年12月于西北妇女儿童医院生殖中心行IVF/ICSI新鲜周期胚胎移植的患者(共9 188例)的临床资料,以获卵数不同将患者分为5组,分别为获卵1~3枚组、4~7枚组、8~13枚组、14~19枚组、≥20枚组,比较各组患者的基本情况及胚胎发育情况,以及继续妊娠率、周期取消率等临床结局。结果各组患者随着年龄减少,获卵数、双原核(2PN)胚胎数、可用胚胎数及优质胚胎数显著增加(P<0.05)。获卵8~13枚组的继续妊娠率显著高于1~3枚组、4~7枚组(P<0.05),且其周期取消率显著低于1~3枚组、14~19枚组及≥20枚组(P<0.05);其OHSS率亦显著低于14~19枚组及≥20枚组,无可用胚胎率显著低于1~3枚组、4~7枚组(P均<0.05)。结论在GnRH激动剂促排卵方案中,获卵数8~13枚时继续妊娠率较高,且周期取消率及OHSS发生率较低,是新鲜周期胚胎移植较适宜的获卵数。
Objective： To explore the optimum number of oocytes retrieved with GnRH agonist protocol in IVF-ET. Methods： The data of 9 188 fresh IVF cycles in ART center of Northwest Women＇s and Children＇s Hospital from January 2014 to December 2015 were retrospectively analyzed. All the cycles were divided into 5 groups according to the number of oocytes retrieved, group A （1-3 oocytes） ,group B （4-7 oocytes）, group C （8-13 oocytes）,group D （14-19 oocytes） and group E （920 ooeytes）. The ongoing pregnancy rate, cycle cancel rate and canceled by OHSS rate were compared among the groups. Results： The number of oocytes retrieved,the number of available embryos ＆ high quality embryos were increased significantly along with the decrease of age of the patients （P 〈 0.05）. The ongoing pregnancy rate in group C （54.9%） was significantly higher than group A （33.4%） ,group B （47.0%） （P 〈0.05） ,and the cycle cancellation rate （18.2%） was significantly lower than group A （37.2%） ,group D （36.6%） and group E （59.0%） （P〈0.05）. The OHSS rate in group C was significantly lower than group D and E,and the rate of no available embryos was significantly lower than group A and B （P〈0.05）. Conclusions： The optimum number of ooeytes retrieved with GnRH agonist protocol is 8-13 oocytes in fresh IVF cycles clue to that the ongoing pregnancy rate is higher and cycle cancelltion rate ＆ OHSS incidence are lower.
出处
《生殖医学杂志》
CAS
2017年第6期511-515,共5页
Journal of Reproductive Medicine
基金
陕西省科学技术社发公关项目(2015SF210)
陕西省卫生厅科研项目(2014D89)
