摘要
目的考察硝苯地平的生物利用度。方法建立测定大鼠血浆中硝苯地平的HPLC方法测定血药浓度,静脉注射硝苯地平(剂量0.75mg·kg^(-1))与口服给药硝苯地平(剂量3mg·kg^(-1))测定血药浓度。结果经拟合得出i.v.符合两室模型,i.g.符合一室模型,计算绝对生物利用度为38.02%。结论结果表明硝苯地平在大鼠体内的绝对生物利用度较低。
OBJECTIVE To study the bioavailability of nifedipine. METHODS To establish a HPLC method for the determination of nifedipine in rats plasma. The blood drug concentration was determined after intravenous in- jection of nifedipine （0.75mg · kg^-1 ） and oral administration of nifedipine （3mg · kg^-1 ）. RESULTS The resluts showd that oral administation met one compartment model and intravenous administration met two compartment mod- el. The absolute bioavailability is 38.02%. CONCLUSION The results showed that the absolute bioavailability of nifediDine was low in rats.
出处
《海峡药学》
2017年第5期21-23,共3页
Strait Pharmaceutical Journal
