摘要
表观遗传学修饰是指在DNA序列未变化的情况下发生的可遗传的基因表达的变化,主要机制包括DNA甲基化、组蛋白修饰、非编码RNAs、染色质修饰等。骨质疏松症(osteoporosis,OP)是一种最常见的骨组织疾病,其特征是骨强度下降和微细结构破坏,患者发生骨折的风险增加,通常是由于新骨形成不足以补偿过度的骨吸收。目前认为表观遗传学调控在OP的发生和发展中起重要意义。表观遗传学修饰广泛参与成骨细胞和破骨细胞分化及成骨-骨细胞转变过程中重要基因表达的调控及成骨细胞和破骨细胞的交互作用。针对表观遗传学机制的药物初步显示了在OP治疗中的前景。
Epigenetic modification indicates the inheritable alteration of gene expression without changing DNA sequence, including DNA methylation, histone modifications, non-coding RNAs and chromatin modifications etc. Osteoporosis is the most common bone disease characterized by decreased bone strength and bone micro-architectural deterioration, an increased risk of fractures. Nowadays it is well accepted that epigenetic regulation is deeply involved in the occurrence and development of osteoporosis. Epigenetic modification regulates the expression of important genes in the differentiation of osteoblasts and osteoclasts and osteoblast-to-osteocyte transition, even the crosstalk between osteoblasts and osteoclasts. Epigenetically active drugs have already shown potential for the treatment of osteoporosis.
出处
《中华骨质疏松和骨矿盐疾病杂志》
CSCD
2017年第3期290-296,共7页
Chinese Journal Of Osteoporosis And Bone Mineral Research
