摘要
目的了解婴幼儿血管瘤(infantile hemangioma,IH)发生的流行病学特点,探索IH发生的可疑危险因素。方法选取363例0~2岁血管瘤患儿及332例非血管瘤患儿进行病例对照研究。对进入入选标准的患儿父母发放调查问卷,内容涵盖婴儿出生情况、父母孕前1年及孕期的生活行为方式及可能的环境危险因素等共37项,通过回归分析以了解IH的流行病学特点及发现IH发生的危险因素。结果单因素卡方、t检验和秩和检验筛选出19个P<0.05的因素进行多因素Logistic回归分析,最终婴儿性别、出生体重、孕周、母亲生育年龄、胎数、产次、妊娠期高血压、孕期异常、胎盘异常、孕期使用保胎药物、反季节蔬菜水果、母亲接触化肥、父母工作中接触有害物质(P<0.05)共14个因素进入Logistic回归模型,均为血管瘤发病的独立危险因素。结论除婴儿性别外,母亲生育史、父母孕期及孕前1年部分生活行为习惯包括出生体重、孕周、母亲生育年龄、胎数、产次、妊娠期高血压、孕期异常、胎盘异常、孕期使用保胎药物、反季节蔬菜水果、母亲接触化肥、父母工作中接触有害物质可能是婴幼儿血管瘤发生的高危因素。
Objective To understand the epidemiological characteristics of infantile hemangioma and exploring the risk factors of infantile hemangioma. Methods A case-control study was conducted between 363 cases of 0 - 2 years old children with hemangioma and 332 children with non-hemangioma. Release the questionnaire to the parents of the children who entered the inclusion criteria. The birth history, the behavior and potential risks factors of parents during the year before pregnancy and gestation period was included in a questionnaire with a total of 37 items. To use regression analysis to understand the epidemiological characteristics and explore independent correlation of infantile hemangioma. Results Single factor X2 test, t test or rank-sum test in- spectioning out 19 variables with P 〈 0. 05 to undergo multivariate Logistic factors regression analysis. A total of 14 risk factors were shown to be associated with infantile hemangioma with multiple Logistic regression a- nalysis which including the infant sex, gestational age, fetus number, low birth weight, preterm birth, gesta- tional hypertension, gestational period anomalies, placental anomalies, tocolytic drug （ progester-one ）, anti- season vegetables and fruits, maternal contacting with fertilizer, maternal contacting with toxic substances, pa- ternal contacting with toxic substances （ P 〈 0. 05 ） were independent risk factors for infantile hemangio- ma. Conclusion Besides the baby gender,in many aspects such as the maternal birth history, parents living habits during the year before pregnancy and gestational period including gestational age, fetus number, low birth weight, preterm birth, gestational hypertension, gestational period anomalies, placental anomalies, toco- lytic drug （progester-one）, anti-season vegetables and fruits, maternal contacting with fertilizer, materual con- tacting with toxic substances, paternal contacting with toxic substances may be possible factors for developing IHs.
出处
《中国皮肤性病学杂志》
CSCD
北大核心
2017年第6期619-622,626,共5页
The Chinese Journal of Dermatovenereology
