摘要
目的:应用Meta分析方法研究基质金属蛋白酶MMP-1-1607 bp 1G/2G多态性和口腔癌易感性的关系。方法:检索各大数据库中符合纳入MMP-1-1607 bp 1G/2G启动子基因多态性与口腔癌易感性关系的病例对照研究,在各种不同遗传模型中进行对比,基因多态性与易感性的关系用比值比(OR)及95%可信区间(CI)表示,应用Rev Man 5.3软件对数据进行分析。结果:共纳入5篇研究,基于随机效应模型的Meta分析发现,1G/2G VS.2G/2G遗传模型OR=0.80,95%CI为0.53-1.20;1G VS.2G遗传模型OR=0.77,95%CI为0.54-1.11;2G/2G VS.1G/2G+1G/1G遗传模型OR=1.34,95%CI为0.87-2.06;1G/1G VS.1G/2G+2G/2G遗传模型OR=0.69,95%CI为0.36-1.36.结论:目前的文献尚不能证明MMP-1-1607 bp 1G/2G多态性和口腔癌易感性相关。
Objective ： To evaluate the association between matrix metalloproteinase-1 （ MMP-1 ） -1607 （1G/2G） polymorphism in promoter region and susceptibility of oral cancer by Meta-analysis. Methods： Case-control studies evaluating the relationship between matrix metalloproteinase-1 （ MMP-1 ） -1607 （1G/2G） polymorphism in promoter region aml susceptibility of oral cancer were searched in electronic databases and compared in the different genetic model. Odds ratio（OR） and 95% confidence interval（CI） were used to express the relationship between polymorphism and susceptibility. RevManS. 3 software was applied for data analysis. Results： A total of 5 studies were extracted for systematic review. Meta-analysis which based on random effects model showed that OR （ 95 % CI） = 0. 80 （ 0. 53-1.20） under 1G/2G VS. 2G/2G model, OR （ 95 % C1） = 0. 77 （0. 54-1.11 ）under 1 G VS. 2G model, OR （95 % CI） = 1.34 （0. 87-2. 06） under 2G/2G VS. 1 G/2G ＋ 1 G/1 G model and OR （95% CI） = 0. 69 （0. 36-1.36 ） under 1G/1G VS. 1G/2G ＋ 2G/2G model. Conclusion ： Current literatures can not confirm that there was significant association between MMP-1-1607 （1G/2G） polymorphism in promoter region and susceptibility of oral cancer.
出处
《临床口腔医学杂志》
2017年第5期270-272,共3页
Journal of Clinical Stomatology
基金
国家自然科学基金青年科学基金项目(81500830
81502258)
